The purpose of the study was to investigate the antioxidant characteristics of Anisomeles indica methanol extract and the inhibitory effect of ovatodiolide on melanogenesis. In the study, the antioxidant capacities of A. indica methanol extract such as DPPH assay, ABTS radical scavenging assay, reducing capacity and metal ion chelating capacity as well as total phenolic content of the extract w...

Currently, aloesin is used in the cosmetic industry as a whitening agent because it inhibits tyrosinase activity. Aloesin is a C-glycosylated chromone compound isolated from aloe, and it is difficult to synthesize because of C-glycosyl moiety in the molecule. The purpose of this study is to search for a new chromone compound which is easy to synthesize and which posesses stronger tyrosinase inh...

In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with ...

For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoi...

Background and objectives: Phytochemical studies have shown that the Phlomis species are rich in polyphenolics and iridoid glycosides and many of them have shown potential value in different biological and pharmacological activities. In this study, we evaluated the effect of Phlomis persica, P. brugieri, P. olivieri and P. anisodontea</em...

Rosmarinic acid isolated from the Perilla frutescens (L.) was found to possess mushroom tyrosinase (EC 1.14.18.1) inhibitory activities with an IC50 of 4.0 μM. However, rosmarinic acid was oxidized as a substrate catalyzed by tyrosinase. The oxidation kinetics of mushroom tyrosinase by rosmarinic acid measured by spectrophotometic and polarographic methods showed Km=166.8 μM, 225.1 μM and Vmax=...

the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

The aim of this study was to investigate the effect of ethyl acetate fraction of Euryale ferox seed extracts (Efse-EA) on melanogenesis in immortalized mouse melanocyte cell line, melan-a. Efse-EA showed strong dose-dependent mushroom tyrosinase inhibitory activity. Treatment of melan-a cells with 30 μg/mL Efse-EA produced strong inhibition of cellular tyrosinase and melanin synthesis. Efse-EA ...

tyrosinase has been recognized as a major autoantign in human vitiligo. here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete freund’s adjuvant in c57bl/6 mice. the onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. our results con...