Thymic precursors expressing the pre-T cell receptor (TCR), the gammadeltaTCR, or the alphabetaTCR can all enter the CD4+ 8+ alphabeta lineage, albeit with different efficacy. Here it is shown that proliferation and differentiation of precursors with the different TCRs into alphabeta lineage cells require Notch signaling at the DN3 stage of thymic development. At the DN4 stage, Notch signaling ...

To determine the phenotypes of cytotoxic cells in channel catfish, clonal alloantigen-dependent leukocyte lines were established from mixed leukocyte cultures. Each clone was analyzed for expression of TCR alpha and beta genes by RT-PCR and for target cell specificity by 51Cr-release assay. Based on the above criteria, the following five different cell types were identified among the 19 clones ...

We considers how a particular kind of graph corresponds to multiplicative intuitionistic linear logic formula. The main feature of the graphical notation is that it absorbs certain symmetries between conjunction and implication. We look at the basic definitions and present details of an implementation in the functional programming language Standard ML. This provides a functional approach to gra...

In this paper, we introduce the notions of $(odot, oplus)$-derivations and $(ominus, odot)$-derivations for $MV$-algebras and discuss some related results. We study the connection between these derivations on an $MV$-algebra $A$ and the derivations on its boolean center. We characterize the isotone $(odot, oplus)$-derivations and prove that $(ominus, odot)$-derivations are isotone. Finally we d...

After introducing double derivations of $n$-Lie algebra $L$ we‎ ‎describe the relationship between the algebra $mathcal D(L)$ of double derivations and the usual‎ ‎derivation Lie algebra $mathcal Der(L)$‎. ‎In particular‎, ‎we prove that the inner derivation algebra $ad(L)$‎ ‎is an ideal of the double derivation algebra $mathcal D(L)$; we also show that if $L$ is a perfect $n$-Lie algebra‎ ‎wit...

The study was undertaken to further elucidate a role of gonadal hormones in maintenance of normal thymocyte maturation and sexual dimorphism in the intrathymic T-cell development. Rats of both sexes were gonadectomized or sham-gonadectomized (controls) at age of 2 and 6 months, and 30 days later the thymus size, cellularity and thymocyte composition were evaluated. In both control and gonadecto...

The humoral immune response to Borrelia burgdorferi during persistent infection is critical to both protective and disease-resolving immunity. This study examined the role of B cells in the absence of T cells during these events, using mice with selected immune dysfunctions. At 6 weeks postinfection, an interval at which arthritis resolves in immunocompetent mice, arthritis severity was equival...

Let  be a Banach algebra. Let  be linear mappings on . First we demonstrate a theorem concerning the continuity of double derivations; especially that all of -double derivations are continuous on semi-simple Banach algebras, in certain case. Afterwards we define a new vocabulary called “-higher double derivation” and present a relation between this subject and derivations and finally give some ...

Some sufficient conditions on a Symmetric Monoidal Closed category K are obtained such that a diagram in a free SMC category generated by the set A of atoms commutes if and only if all its interpretations in K are commutative. In particular, the category of vector spaces on any field satisfies these conditions (only this case was considered in the original Mac Lane conjecture). Instead of diagr...