BACKGROUND: The simultaneous occurrence of cerebellopontine angle (CPA) meningioma and vestibular schwannoma (VS) in the absence of neurofibromatosis type 2 or history of irradiation is very rare. We report a case with coexistent CPA meningioma and VS, which were radiologically not distinguishable in preoperative imaging. CASE DESCRIPTION: A 46-year-old female presented with acute hearing loss,...

The coexistence of schwannoma and meningioma in the same cerebellopontine angle (CPA) is uncommon. Especially, the presence of a single mixed tumour composed of demarcated or intermingled components of schwannoma and meningioma tissue is extremely rare. Such a phenomenon is mainly reported in a patient with NF2 or with history of previous irradiation. We present two cases of simultaneous occurr...

Spontaneous internal carotid artery dissection (SICAD) has classically been associated with a good prognosis and many clinicians treat it conservatively.[1] However, a recent study reiterates the very poor recanalization rates in SICAD with complete occlusion.[2] Moreover, collateral flow is critically important in maintaining cerebral perfusion in such patients. Hence our case highlights the o...

BACKGROUND Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear. CASE DESCRIPTION We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of hea...

The coexistence of intracranial aneurysms and a meningioma is not a clinically common phenomenon. Here we present the case of a meningioma of the left anterior clinoid process concurrent with a right clinoid aneurysm and a ruptured aneurysm of the left post communicating artery (PcomA). Immediately after radiographically establishing a diagnosis of multiple aneurysms and to reduce the risk of r...

Meningiomas are the tumors which are found in cases of multiple intracranial tumors of different histology. This is attributed to frequent occurrence of intracranial meningiomas and their long clinical evolution before diagnosis. Thus, they have an increased probability of simultaneously harboring another primary or secondary intracranial tumors. Central nervous system (CNS) melanotic tumors in...

BACKGROUND Immortal cell lines and cell lines derived from operative specimens transplanted into animal models are used in meningioma research. We address 2 criticisms of the mouse xenograft flank tumor model: Why are tumor induction rates derived from operative specimens low and inconsistent? Are flank tumors meningiomas? METHODS Meningioma cell cultures were processed for Giemsa-band karyot...

OBJECTIVES The clinical management of meningioma is guided by tumor grade and biological behavior. Currently, the assessment of tumor grade follows surgical resection and histopathologic review. Reliable techniques for pre-operative determination of tumor grade may enhance clinical decision-making. METHODS A total of 175 meningioma patients (103 low-grade and 72 high-grade) with pre-operative...

The major known genetic contributor to meningioma formation was NF2, which is disrupted by mutation or loss in about 50% of tumors. Besides NF2, several recurrent driver mutations were recently uncovered through next-generation sequencing. Here, we performed whole-genome sequencing across 7 tumor-normal pairs to identify somatic genetic alterations in meningioma. As a result, Chromatin regulato...

Background: Meningiomas are common central nervous system (CNS) tumors that account for thirty percent of primary intracranial tumors.. The accuracy of predicting meningioma recurrence and progression is not enough. So, there is a real need for discovering recent factors for identification of the relapse risk, progression rates, which patients will need aggressive treatment and predicting and i...