Background Thrombolytic therapy reduces mortality after acute myocardial infarction, even when treatment is initiated relatively late after onset of symptoms. The mechanism underlying this survival benefit is incompletely understood. Methods and Results In a prospectively designed ancillary study of a randomized, placebo-controlled trial of late thrombolytic therapy (LATE), the signal-averaged ...

Multicenter clinical research studies are often needed to address issues of generalizability, conditions with low incidence, adequate statistical power, and potential study bias. While pediatric research networks began work in the 1950s, and Rhode Island physicians have contributed to many of these studies, pediatric emergency medicine (PEM) collaboratives are relative newcomers. Since the mid-...

I was gratified to learn that Dr. Kim and colleagues found the Iowa Satisfaction with Anesthesia Scale [1] useful for comparing patient satisfaction between dexmedetomidine and propofol/alfentanil groups during cataract surgery [2]. Fung and colleagues found reliability and validity for cataract surgery patients among English speaking patients [3]. A recent multicenter center showed reliability...

Introduction Quality control (QC) protocols are now routinely used on clinical Magnetic Resonance Imaging (MRI) devices. Most of the time, these QC procedures are manufacturer-specific, and then not useable for multicenter projects involving multiple MRI systems from different vendors on different sites. The aim of the work package 1 of the Grand Ouest Glioblastoma Project (GOGP) [1], a multice...

the platform switching (pls) concept was introduced in the literature in 2005. the biological benefits and clinical effectiveness of the pls technique have been established by several studies. in this article different aspects of pls concept are discussed. crestal bone loss, biologic width, and stress distribution in this concept are comprehensively reviewed. in this article the relative publis...

Increasingly, investigators rely on multicenter or multigroup studies to demonstrate effectiveness and generalizability. Authors too often overlook the analytic challenges in these study designs: the correlation of outcomes and exposures among patients within centers, confounding of associations by center, and effect modification of treatment or exposure across center. Correlation or clustering...

A novel procedure for deriving multicenter bond indices on the basis of irreducible spinless charge density matrices that are naturally introduced as in the Ursell–Mayer theory is presented. Unlike earlier schemes using central moments of the charge operator, the procedure presented here leads to a proper definition of multicenter bond indices for an arbitrary number of atoms. Formal relationsh...

Background and Purpose The aims of this prospective and multicenter study were to determine the frequency of anticardiolipin and antinuclear antibodies in an unselected ischemic and hemorrhagic stroke population and to evaluate the clinical significance of these autoantibodies. Methods Over a 1-year period, we collected plasma from 481 consecutive patients with ischemic or hemorrhagic stroke at...

AIM To understand stakeholders' views on data sharing in multicenter comparative effectiveness research studies and the value of privacy-protecting methods. MATERIALS & METHODS Semistructured interviews with five US stakeholder groups. RESULTS We completed 11 interviews, involving patients (n = 15), researchers (n = 10), Institutional Review Board and regulatory staff (n = 3), multicenter r...

Background—Previous studies suggested that transplantation of autologous bone marrow–derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Methods and Results—Patients 18 to 75 years of age with chronic chagasic cardiomyopathy, New York Heart Associatio...