The clinical potential of cell-based therapies is limited by poor targeting of systemically infused cells to diseased tissues [1]. In our recent study, we have developed a multi-step screening platform to identify small molecules that boost the homing properties of mesenchymal stem cells (MSCs) to sites of inflammation [2]. First, a medium-throughput screen was designed to identify small molecu...

The structure of the Internet serves as a big "commoditizer" of all traffic. Therefore all data, be it time critical or not is transported at the same speed. However, recent trends in the internet are changing this structure. The practices of multi-homing and using content delivery networks reduce the commodity nature of data being transported and put terminating Internet service providers in a...

Cloud storage multi-homing (a.k.a. as multicloud) represents a possible solution to achieve enhanced availability of one’s own data and build an extremely reliable cloud environment out of relatively unreliable single cloud platforms. However, subscribing with multiple cloud providers comes at a cost. The cost of multiple subscriptions must be compared against the damage resulting from the poss...

Objective(s):The limited homing potential of bone-marrow-derived mesenchymal stem cells (BM-MSC) is the key obstacle in MSC-based therapy. It is believed that chemokines and chemokine receptor interactions play key roles in cellular processes associated with migration. Meanwhile, MSCs express a low level of distinct chemokine receptors and they even lose these receptors on their surface after a...

The effect of Kutum (Rutilus firisi kutum) stock enhancement for homing behavior and imprinting with morpholine were studied during 2004 to 2008. This species is a migratory anadromous fish, spawning in rivers in March–April. It has a group synchronous and single spawning behavior. Total of 15,930 Tagged (ABC Tags) specimens of Kutum fingerlings were released into the Khoshkroud river estuary...

clinical applications of mesenchymal stem cells (mscs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. homing and engraftment capacity of these stem cells depend on the expression of chemokines and their receptors. ex vivo expanded mscs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...

A proper support for multimedia communications transport has to provide fault tolerance capabilities such as the preservation of established connections in case of failures. While multi-homing addresses this issue, the currently available solution based in massive BGP route injection presents serious scalability limitations, since it contributes to the exponential growth of the BGP table size. ...

SCTP (Stream Control Transport Protocol) is a reliable transport layer protocol which provides acknowledged, error-free and non-duplicated transfer of message. It combines the advantages of TCP and UDP. In additional to that, SCTP has many attractive characteristics such as multi-homing, multi-streaming and partial data reliability. This paper thoroughly discusses about the advantages of SCTP. ...