Kawasaki disease (KD) is a mucocutaneous lymph node syndrome, and was first described in Japan in 1967. Physiopathologically, it is an acute necrotizing vasculitis of the mediumand small-sized arteries. According to surveillance research from 2013 to 2014 in Japan, the sex ratio (male/female) was 1.28. KD often occurs in children and adult cases are very rare. The incidence rate (from 0 to 4 ye...

AFRICA 37 with medical therapy and referred for coronary artery bypass grafting. discussion KD is a febrile disorder of unknown cause with multiple systemic manifestations, affecting primarily infants and young children. 4 First described in Japan by Kawasaki in 1967 as acute mucocutaneous lymph node syndrome, it has been reported with increasing frequency around the world. Involvement of the h...

It has been 28 years since Dr. Tomisaku Kawasaki originally described mucocutaneous lymph node syndrome, now known as Kawasaki disease.! First thought to be a benign self-limited febrile illness, Kawasaki disease today is recognized as the most common cause of acquired heart disease in children in the United States. It is almost exclusively an illness of young children about 80 percent of patie...

In drug development, non-inferiority tests are often employed to determine the difference between two independent binomial proportions. Many test statistics for non-inferiority are based on the frequentist framework. In this paper, we propose a method for the determination of sample sizes using the index ( ) , , 2 1 0 2 1 X X P ∆ − π > π = τ where 1 X and 2 X denote binomial random variables fo...