Denote a⊕ b = max(a,b), and a⊗ b = a+ b, for a,b ∈ R and extend this pair of operations to matrices and vectors in the same way as in conventional linear algebra, that is if A = (ai j),B = (bi j),C = (ci j) are real matrices or vectors of compatible sizes then C = A⊗ B if ci j = ⊕ k aik ⊗ bk j for all i, j. For any n× n matrix A = (ai j) and for arbitrary sequence of real parameters α = (α1, . ...

One of the most popular and simple models for the calculation of pK(a) s from a protein structure is the semi-macroscopic electrostatic model MEAD. This model requires empirical parameters for each residue to calculate pK(a) s. Analysis of current, widely used empirical parameters for cysteine residues showed that they did not reproduce expected cysteine pK(a) s; thus, we set out to identify pa...

In this paper, we empirically analyze weekly advertising policies of manufacturing firms in consumer goods markets. We assume firms engage in persuasive advertising, thus policies of firms affect the goodwill of a brand. We introduce a demand and a goodwill production function. A simple transformation of the demand function allows us to identify not only the demand parameters but also the param...

This article is motivated by an application where subjects were dosed three times with the same drug and the drug concentration profiles appeared to be the lowest after the third dose. One possible explanation is that the pharmacokinetic (PK) parameters vary over time. Therefore, we consider population PK models with time-varying PK parameters. These time-varying PK parameters are modeled by na...

Malignant Pleural Effusions (MPE) may be useful as a model to study hierarchical progression of cancer and/or intratumoral heterogeneity. To strengthen the rationale for developing the MPE-model for these purposes, we set out to find evidence for the presence of cancer stem cells (CSC) in MPE and demonstrate an ability to sustain intratumoral heterogeneity in MPE-primary cultures. Our studies s...

purpose : to compare outcomes of penetrating keratoplasty (pk) and deep anterior lamellar keratoplasty (dalk) in keratoconic eyes in a university teaching hospital setting methods : in this longitudinal cross-sectional study all patients who underwent pk or dalk for keratoconus at 2 years period were included to the study. the patients were recalled and complete eye examination including best s...

purpose: to investigate the biomechanical features of transplanted corneas after penetrating keratoplasty (pk), deep anterior lamellar keratoplasty (dalk), and descemet stripping automated endothelial keratoplasty (dsaek) and compare these measurements with those of a normal group. methods: forty-five eyes of 36 patients underwent pk, 23 eyes of 21 patients received dalk using anwar’s big bubbl...

CD163+ tumor-associated macrophages (TAMs) play an important role in the progression of cancer. However, the significance of CD163+ TAMs in malignant pleural effusion (MPE) is still unclear. The aim of this study is to evaluate the prognostic value of CD163+ TAMs in MPE, and the regulatory effect of an immune adjuvant (pseudomonas aeruginosa - mannose-sensitive hemagglutinin, PA-MSHA, which is ...

An integrated pharmacokinetics (PK) model that simultaneously describes concentrations of total antibody (Tab) and antibody-conjugated monomethyl auristatin E (acMMAE) following administration of monomethyl auristatin E (MMAE)-containing antibody-drug conjugates (ADCs) was developed based on phase I PK data with extensive sampling for two ADCs. Two linear two-compartment models that shared all ...