نتایج جستجو برای: morphine withdrawal signs

تعداد نتایج: 141960  

Journal: :iranian journal of pharmaceutical research 0
navid abbasi maleki departement of pharmacology, urmia branch, islamic azad university, urmia, iran. saeid abbasi maleki departement of pharmacology, urmia branch, islamic azad university, urmia, iran. reza bekhradi research development and training center, barij essence pharmaceutical co, kashan, iran.

this research was done to test the effect of rosa damascena essential oil on withdrawal signsof naloxone-precipitated morphine in male mice. morphine dependence was induced by injection(ip) three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. on day 4,after the last administration of morphine, rosa damascena essential oil was administered atdifferent concentrations (5, 2...

2010
Javier Navarro-Zaragoza Cristina Núñez M. Luisa Laorden Victoria Milanés

The role of stress in drug addiction is well established. The negative affective states of withdrawal most probably involve recruitment of brain stress neurocircuitry (e.g. induction of hypothalamo-pituitary-adrenocortical –HPAaxis, noradrenergic and corticotrophin-releasing factor activity). The present study investigated the role of CRF receptor-1 subtype (CRF1R) on the response of brain stre...

Journal: :Behavioural brain research 1994
S L Cappendijk D Fekkes M R Dzoljic

Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded th...

Journal: :Phytotherapy research : PTR 2009
Amir Feily Naser Abbasi

The effects of Hypericum perforatum (St John's wort) on morphine withdrawal syndrome and comparison with clonidine have been investigated in morphine-dependent rats. Adult male Wistar rats were subjects. The frequencies of withdrawal behavioral signs (rearing, teeth chattering and jumping) induced by naloxone challenge were demonstrated in morphine dependent rats receiving Hypericum perforatum ...

امینی, حسن, ایزدپناه, اسماعیل, حسن زاده, کامبیز, رامان مولودی, محمد,

Background and purpose: The exact mechanisms of morphine dependence and withdrawal syndrome remain unclear. Many studies have been performed to find a drug for prevention of withdrawal symptoms. The aim of this study was to evaluate the effect of mefloquine (a gap junction inhibitor) on morphine withdrawal symptoms in male rats. Materials and methods: In an experimental study, adult male Wista...

Journal: :iranian journal of basic medical sciences 0
mohammad allahtavakoli department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran physiology- pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran ruhollah moloudi department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran mohammad ebrahim rezvani department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran ali shamsizadeh department of physiology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran physiology- pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran

objective(s) opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. in the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. materials and methods addiction was induced by progressive incremental doses of morphine over 7 days. behavioral signs...

Journal: :Neuroscience letters 2011
Xian-Fu Lu Yuan-Yuan Li Chun-Guang Wang Jin-Qiu Wei Ying Ye Li-Cai Zhang Jun-Li Cao

The cerebrospinal fluid-contacting nucleus (CSF-CN), distributes and localizes in the ventral periaqueductal central gray (PAG) of the brainstem, which may influence actual composition of the cerebrospinal fluid (CSF) for non-synaptic signal transmission via releasing or absorbing bioactive substances. Many experiments have demonstrated that substance P (SP), a substance that is shown to be up-...

Journal: :مجله دانشگاه علوم پزشکی کرمانشاه 0
mahnaz ghowsi namdar yousofvand razi university ali pourmotabbed

background: the study was performed to investigate the effects of morphine dependency and morphine withdrawal on the reproductive system of adult male rat(wistar).  methods: 32 adult male rat divided into 5 groups. animals in the control group (n=8) received normal saline (1ml/kg) twice daily subcutaneously for 30 consecutive days. animals in dependent group (n=8) received morphine (10mg/ml/kg)...

H Alaei M Hosseini MR Sharifi MS Shafeia

The mechanisms of drug dependence and rewarding properties of opiates are not exactly known and several neurotransmitters seem to be involved. It is possible that the rennin-angiotensin system could interact with the opioid system, since it has been shown that angiotensin II(Ang) and ACE inhibitors have analgesic, anticonvulsant and antidepression effects and in some cases they could antagonize...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1990
K Rasmussen D B Beitner-Johnson J H Krystal G K Aghajanian E J Nestler

We have compared the time course of the behavioral manifestations of opiate withdrawal to the in vivo activity of locus coeruleus (LC) neurons and to increases in the levels of G-proteins, adenylate cyclase, and cAMP-dependent protein kinase known to occur in the LC in opiate-dependent animals. Rats were given morphine by daily subcutaneous implantation of morphine pellets for 5 d. On the sixth...

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