Geissoschizine is a very important biosynthetic intermediate of monoterpenoid alkaloids in higher plants. In this study, the enantioselective and stereodivergent total syntheses geissoschizine two related indole (villocarine A apogeissoschizine) were achieved. The three synthesized natural products are represented as Nishikigoi (varicolored carp), which also called “swimming jewels” Japan, casc...

Background: Acute lung injury (ALI) is among the most serious conditions characterized by an exacerbation of inflammatory response that can result from a persistent infection. Carvone chiral monoterpenoid ketone present in essential oils dill, caraway, and spearmint. It shows antioxidant, anti-inflammatory, antimicrobial effects others. In this study, anti-inflammatory protective potential mech...

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol (200 mg/kg) caused a significant decrease in the ...

We have previously reported the use of a combination of computational simulations and targeted experiments to build a first generation mathematical model of peppermint (Menthaxpiperita) essential oil biosynthesis. Here, we report on the expansion of this approach to identify the key factors controlling monoterpenoid essential oil biosynthesis under adverse environmental conditions. We also inve...

X-Ray crystal structures are reported for five silver(I) complexes of four monoterpenoid alkenes. Discrete mononuclear complexes of the chiral alkenes (1S)-(-)-α-pinene and (1S)(-)-β-pinene with silver perchlorate and silver hexafluorophosphate are described. The achiral diene γ-terpinene forms a discrete mononuclear adduct with silver hexafluorophosphate and a two-dimensional polymeric network...

Three new meroterpenoids, guajavadials A-C (1-3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adduc...