To the Editor, A 70-year-old man (with a diagnosis of Wegener Granulomatosis (WG)) was seen for weakness in his hands and feet predominantly on the right side. His complaints had started with a right-sided paresthesia and drop foot 6 months ago, and laboratory studies (at that time) had been as follows – erythrocyte sedimentation rate: 84 mm/h (0-20 mm/h), C-reactive protein: 47.6 mg/l (0-3 mg/...

Eosinophilic granulomatosis with polyangiitis formerly named “Churg-Strauss syndrome (CSS)” is a systemic disease with bronchial asthma, hypereosinophilia, and systemic vasculitis. We report a case of CSS with cholecystitis and mononeuritis multiplex. A 50-year-old woman with a history of sinusitis and bronchial asthma of 8 years’ duration was referred with a complaint of left-hand deformity an...

Background: Herpes simplex virus (HSV) is a neurotropic DNA with high prevalence. Following primary infection, HSV remains dormant in the neural ganglia. Secondary infection can emerge after reactivation of latent presenting as neurological manifestations. Previous studies have demonstrated relationship between and selective involvement cranial nerves. Depending on affected nerve, mononeuropath...

Unilateral facial nerve palsy (FNP) is one of the most common cranial mononeuropathies. Among rare etiologies, neurosarcoidosis (NS) can cause bilateral involvement (both recurring and simultaneous) only in 15% to 25% cases. The rarity this systemic disease its clinical heterogeneity, due granulomatous inflammation that may affect many anatomic substrates, frequently make diagnosis a real chall...

The association between the use of statins and neuromuscular disease is currently being intensely discussed. We relate a 63 years old man with possible case of statin-induced neuropathy in a patient with dislipidemia in use of simvastatina at high doses. The electrophysiologic studies disclosed findings compatible with mononeuropathy multiplex, suggested by clinical prescutation of asymmetrical...

OBJECTIVE This study aimed to determine the usefulness of sural nerve biopsy in neurological practice. METHODS The first prospective study of sural nerve biopsy in 50 consecutive patients was undertaken. The investigating neurologist declared the prebiopsy diagnosis and management plan and after 3 months an independent neurologist evaluated the contribution of the biopsy to diagnosis and mana...

A unique case of a body building champion with localised atrophy of the distal portion of the vastus lateralis muscle is reported; neurophysiological evaluation suggests a selective lesion of a distal branch of the vastus lateralis nerve (a motor branch of the femoral nerve). A necroscopic study in four cases was performed to better clarify the site and mechanism of nerve lesion. The data sugge...

OBJECTIVE To discuss the diagnosis and treatment of meralgia paresthetica as reported in the literature and as experienced by the author. SUMMARY BACKGROUND DATA Meralgia paresthetica is a mononeuropathy of the lateral femoral cutaneous nerve that can lead to significant disability when the diagnosis and treatment is delayed or missed. This condition is relatively common but is frequently mis...

The present study was performed in rats with experimentally induced mononeuropathy after left common sciatic nerve ligation. The hindpaw withdrawal latencies to thermal and mechanical stimulation increased significantly after intra-periaqueductal grey injection of 2 or 3 nmol, but not 1 nmol of galanin in rats with mononeuropathy. Intraperitoneal administration of 4.5 mg/kg morphine induced sig...