Aminoglycoside interactions with various phospholipids were measured in three model systems and compared with the ototoxicities of the drugs: (a) competition for [14C]neomycin binding; (b) competition for 45Ca2+ binding; and (c) effect on surface pressure of monomolecular lipid films. The efficacies of the antibiotics in displacing neomycin from phosphatidylserine, phosphatidylinositol or phosp...

Success of pig production depends on maximizing return over feed costs and addressing potential nutrient pollution to the environment. Mathematical modeling has been used to describe many important aspects of inputs and outputs of pork production. This study was undertaken to compare 4 mathematical functions for the best fit in terms of describing specific data sets on pig growth and, in a sepa...

A model which describes the competition between chain melting and orientational ordering in a monomolecular layer of long-chain amphiphilic molecules is studied. This model is analogous to the Berker-Cardy-Nelson-Scalapino model for phase transitions in films of 'HeHe mixtures. Their Midgal-Kadanoff renormalization-group approach is applied to the present problem. It reveals two phase transitio...

The finite-temperature dynamics of WAu12, incorporating both electronic and structural effects, is studied using a density-functional-based Born-Oppenheimer molecular dynamics method. Molecular dynamics simulations for monomolecular WAu12 suggest a surface-melting-type behaviour of the angular degrees of freedom between 366 and 512 K. Thermally averaged electron density-of-states of WAu12 are c...

Diagnosis of diseases by different imaging methods can provide complementary information about the functional status of diseased tissues or organs. To overcome the current difficulties in coregistering images from different imaging modalities with a high degree of accuracy, we prepared near-infrared (NIR) monomolecular multimodal imaging agents (MOMIAs) consisting of a heptamethine carbocyanine...