Abstract Bispecific antibodies (bsAbs), though possessing great therapeutic potential, are extremely challenging to obtain at high purity within a limited number of scalable downstream processing steps. Complementary Protein A chromatography, polishing strategies play critical role removing the remaining molecular weight (HMW) and low (LMW) species, as well host cell proteins (HCP) in order ach...

  Abstract   Objective: The aim of this study was to evaluate the efficacy of antibiotic-loaded bone   cement in controlling local infection and in regard to its physical characteristics, elastic   modulus, and tensile strength in-vitro.   Methods: Acrylic bone cement, based on polymethylmethacrylate (PMMA) was   mixed with the powder form of three antibiotics, i.e., gentamicin, tobramycin, and...

Here we describe fast analysis of biomolecules by newly developed pressure-driven liquid chromatography (LC) on a chip with integration of a gradient elution system. We have reported the fabrication of a gradient elution system using a cross-Tesla mixer on a chip with pillar array columns [1]. In this study, we applied the chip to the analysis of biological compounds, and showed that 10 times f...

the aim of this study is to investigate antibacterial effects of immunodominant proteins isolated from the venom of naja naja oxiana snake against staphylococcus aureus, escherichia coli, bacillus subtilis and pseudomonas aeruginosa.the innate immune system is an important line of defense against bacterial diseases. antibacterial proteins produced by snake venoms have recently attracted signifi...

OBJECTIVE This in vitro study was undertaken to evaluate the physical, chemical, and biological properties of commercially available metal orthodontic brackets in South Korea, because national standards for these products are lacking. METHODS FOUR BRACKET BRANDS WERE TESTED FOR DIMENSIONAL ACCURACY, (MANUFACTURING ERRORS IN ANGULATION AND TORQUE), CYTOTOXICITY, COMPOSITION, ELUTION, AND CORRO...

acrylic base resins are widely used in orthopedics and dental surgery. it is generally accepted that due to the incomplete conversion of methyl methacrylate (mma) monomer to the polymer form during polymerization of the resin, some mma monomers remain in the hardened material. mma monomer has been reported to cause abnormalities or lesions in several organs of animals. study of the literatures ...