نتایج جستجو برای: monoamine oxidase

تعداد نتایج: 53778  

Journal: :Science 1960
S SPECTOR P A SHORE B B BRODIE

1-Benzyl-2-methyl-5-methoxytryptamine has been reported, on the basis of indirect evidence, to inhibit monoamine oxidase. More direct experiments, however, demonstrate that the drug is devoid of the ability to block monoamine oxidase in brain in vitro or in vivo.

Journal: :The Biochemical journal 1978
G S Smith R A Reid

Changes in the respiratory state of rat liver mitochondria caused significant changes (up to 10-fold) in the rates of oxidative deamination of tyramine, indicating interactions between the inner coupling membrane and the monoamine oxidase sites in the outer membrane, and suggesting the possibility that monoamine oxidase is regulated by the thermodynamic state of the mitochondria.

Journal: :The Journal of biological chemistry 1977
R H Huang S Eiduson

Spin-labeled hydroxyamphetamine, a competitive reversible inhibitor of brain monoamine oxidase, has been shown to be useful as an electron spin resonance (ESR) probe of the microenvironment of the active sites of the possible monoamine oxidase multiple forms. The ESR spectrum of spin-labeled hydroxyamphetamine was strongly quenched upon binding to the enzyme. The conformation of the active site...

Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...

Journal: :Biochemical Society transactions 1991
R B Silverman

MAO, and analysed the resulting enzyme activity obtained. The transfected cells expressed monoamine oxidase activity of the correct form showing that a single subunit is sufficient to generate activity and that the identified cDNAs code for enzymically active type A and type B monoamine oxidases. The successful expression of the monoamine oxidase cDNAs in a mammalian cell enables the direct stu...

Journal: :The British journal of nutrition 1976
C F Mills A C Dalgarno G Wenham

1. Copper deficiency was induced in five Friesian cattle offered a semi-synthetic diet containing less than 1 mgCu/kg. Changes in blood and liver Cu contents and in the Cu-containing enzymes, ferroxidase I (caeruloplasmin; EC 1.16.3.1) and monoamine oxidase (EC 1.4.3.4) of plasma and cytochrome oxidase (EC 1.9.3.1) of liver and skeletal muscle were monitored during Cu depletion. 2. Rapid decrea...

Journal: :The Biochemical journal 1968
K F Tipton A P Dawson

Activities of the enzymes monoamine oxidase (EC 1.4.3.4), alpha-glycerophosphate dehydrogenase (EC 1.1.99.5) and cytochrome oxidase (EC 1.9.3.1) were determined in homogenates and in the mitochondrial fraction prepared from individual regions of pig brain. The variation in the activity of alpha-glycerophosphate dehydrogenase paralleled that of cytochrome oxidase, but this was not the case with ...

Journal: :Biochemical Society transactions 1977
J F Powell I W Craig

The enzyme monoamine oxidase [monoamine+ oxidoreductase (deaminating), EC 1.4.3.41 is believed to exist in several isoenzymic forms (see Sandler & Youdhim, 1972). On the basis of differential inhibitor sensitivity, Johnston (1968) suggested the existence of two forms of monoamine oxidase, designated A and B. Form A was highly sensitive to the inhibitor clorgyline (M & B 9302), whereas the form ...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006
Georgios I Panoutsopoulos

BACKGROUND/AIMS 3,4-Dimethoxy-2-phenylethylamine is catalyzed to its aldehyde derivative by monoamine oxidase B, but the subsequent oxidation into the corresponding acid has not yet been studied. Oxidation of aromatic aldehydes is catalyzed mainly by aldehyde dehydrogenase and aldehyde oxidase. METHODS The present study examines the metabolism of 3,4-dimethoxy-2-phenylethylamine in vitro and ...

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