introduction: the main purpose of this study was to compare transient ischemic dilation (tid) ratios in spect-low dose ct and spect myocardial perfusion imaging (mpi) by application of different quantitative programs and quantify the possible shift in the upper normal limits of tid ratio in the spect-ct mpi. methods: 149 patients with low pre-test probability for coronary artery disease (cad),...

The introduction of hybrid scanners has greatly increased the popularity of molecular imaging techniques. Many clinical applications benefit from combining complementary information based on the precise alignment of the two modalities. In case the alignment is inaccurate, then this crucial assumption often made for subsequent processing steps will be violated. However, this violation may not be...

Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are functional nuclear medicine techniques which allow for accurate non-invasive in vivo measurements of a wide range of regional tissue functions in man. Brain functional imaging with SPECT and PET is based on the recording of the distribution of administered radionuclides in three dimensions, thus produc...

Molecular imaging with ictal and interictal single-photon emission computed tomography (SPECT) as well as positron emission tomography (PET) rank among the established functional imaging tests for the presurgical evaluation of epileptic onset zone in patients with intractable partial epilepsy. In temporal lobe epilepsy the sensitivity of these methods was shown to be excellent, in particular if...

The role of COX-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic tests for COX-2 expression. Molecular imaging using small molecule probes radiolabelled for both PET and SPECT offer the potential to meet this need, providing a mi...

Background: The standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is represented by concomitant chemo-radiotherapy followed consolidation with durvalumab that ensures a 5-year survival of 46%. However, the risk radiotherapy-induced pneumonia (RIP) almost 10–15%. Complete cardiological examination also usually performed during cardiopulmonary pre-treatment evaluation ...

Molecular imaging techniques such as single photon emission computed tomography (SPECT) or positron emission tomography are promising tools for noninvasive diagnosis of acute allograft rejection (AR). Given the importance of renal transplantation and the limitation of available donors, detailed analysis of factors that affect transplant survival is important. Episodes of acute allograft rejecti...