نتایج جستجو برای: molecular clock

تعداد نتایج: 666755  

Journal: :Diabetes, Obesity and Metabolism 2015

2015
Xin Tong Deqiang Zhang Blake Arthurs Pei Li Leigh Durudogan Neil Gupta Lei Yin Nicolas Cermakian

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in hepatocytes, which coordinates nutritional inputs and hormonal signaling with downstream metaboli...

Journal: :Genetics 2000
D J Cutler

Rates of molecular evolution at some protein-encoding loci are more irregular than expected under a simple neutral model of molecular evolution. This pattern of excessive irregularity in protein substitutions is often called the "overdispersed molecular clock" and is characterized by an index of dispersion, R(T) > 1. Assuming infinite sites, no recombination model of the gene R(T) is given for ...

Journal: :Proceedings of the National Academy of Sciences 1998

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