نتایج جستجو برای: mody
تعداد نتایج: 686 فیلتر نتایج به سال:
The disorder, Maturity Onset of Diabetes of the young (MODY) is a monogenic form of Non-Insulin dependent Diabetes Mellitus (NIDDM), characterized by autosomal dominant mode of inheritance and onset is usually before 25 years of age. Clinical studies of subjects with the different forms of MODY indicate that each is associated with a different defect in the normal pattern of glucose stimulated ...
This paper reports for the first time on the natural history of diabetic retinopathy in three forms of youth onset diabetes seen in our country based on a 4 year follow-up study. Forty patients each with Fibrocalculous Pancreatic Diabetes (FCPD), Maturity Onset Diabetes of Youth (MODY) and Insulin-Dependent Diabetes Mellitus (IDDM) were followed for periods up to four years with annual fundus c...
Prior reports have suggested that variants in the genes for maturity-onset diabetes of the young (MODY) may confer susceptibility to type 2 diabetes, but results have been conflicting and coverage of the MODY genes has been incomplete. To complement our previous studies of HNF4A, we examined the other five known MODY genes for association with type 2 diabetes in Finnish individuals. For each of...
Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Met...
Maturity-onset diabetes of the young (MODY) is a heterozygous monogenic diabetes; more than 13 disease genes have been identified. However, the pathogenesis of MODY is not fully understood, because the pancreatic β-cells of the patients are inaccessable. Therefore, we attempted to establish MODY patient-derived induced pluripotent stem cells (MODY-iPS) cells to investigate the pathogenic mechan...
AIMS Currently, many patients with maturity onset diabetes of the young (MODY) are undiagnosed or misdiagnosed with type 1 or 2 diabetes. This study aims to assess professional experts' views on factors which may influence the current practice of genetic testing for MODY and to explore next steps toward best practice. METHODS Twelve semistructured interviews were conducted with professional e...
background: maturity-onset diabetes of the young (mody) is a heterogeneous entity of monogenic disorders characterized by autosomal dominant inheritance. eleven genes were related, including hnf4α, gck, hnf1α, ipf1, and hnf-1β, and various mutations are being reported. methods: to help the overall understanding of mody-related pathologic mutations, we studied a large mody family found in 2012, ...
AIMS To estimate the UK prevalence of childhood type 2 diabetes and maturity onset diabetes of the young (MODY), and distinguish them from each other and from type 1 diabetes. METHODS The British Society for Paediatric Endocrinology and Diabetes Clinical Trials/Audit Group undertook a cross-sectional questionnaire survey of all paediatric diabetes centres during 2000, collecting data on all c...
Abstract Background A retrospective observational study was conducted to assess the prevalence of maturity onset diabetes young (MODY) in a large paediatric population Southern Italy newly diagnosed with diabetes. Clinical and genetic features identified MODY patients were also described. Methods Genetic testing performed children adolescents who presented autoantibody negativity fasting C-pept...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید