نتایج جستجو برای: modifying drugs
تعداد نتایج: 257803 فیلتر نتایج به سال:
Cardiometabolic disorders, including cardiovascular disease, obesity and type 2 diabetes, are an extreme burden on the health of individuals societies worldwide. The combination genetic susceptibility, environmental lifestyle factors drives disease development. Therefore, understanding exact molecular changes occurring in their pathogenesis brings not only insights into mechanism but also poten...
OBJECTIVE To compare the efficacy of doxycycline plus methotrexate (MTX) versus MTX alone in the treatment of early seropositive rheumatoid arthritis (RA), and to attempt to differentiate the antibacterial and antimetalloproteinase effects of doxycycline. METHODS Sixty-six patients with seropositive RA of <1 year's duration who had not been previously treated with disease-modifying antirheuma...
OBJECTIVES Rheumatoid arthritis (RA) patients are at an increased risk of developing comorbid conditions. A close monitoring of the disease targeting a status of low disease activity is associated with a better outcome. The aim of this trial was to evaluate the impact of a nurse-led programme on comorbidities and the impact of patient self-assessment of disease activity on the management of RA....
Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their disease with disease-modifying antirheumatic drugs (DMARDs), yet this course of therapy is clearly no...
Improvements in the control of inflammation in rheumatoid arthritis (RA) by conventional synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) have led to a substantial change in the clinical outcomes of patients during the last 30 years. Current treatment can lead to sustained remission in some patients raising questions about the optimal management strategies in this subgroup ...
OBJECTIVES The objective of this study was to determine whether physicians' treatment preferences are influenced by patients' age. METHODS We mailed a survey to a random sample of rheumatologists practicing in the US. The survey included a scenario describing a hypothetical patient with rheumatoid arthritis (RA) on hydroxychloroquine, sulfasalazine and low-dose prednisolone, who presents with...
BACKGROUND Patient registry data serves an increasing role in drug safety and comparative effectiveness research, but registry databases often do not contain confounder information measured at the same time that treatments begin. This study evaluated a set of approaches for estimating confounder values at treatment initiation using actual data from a rheumatoid arthritis (RA) registry to examin...
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