Background: Genomic instability is one of primary causes for malignant cell transformation. In this study induced genomic instability expressed as micronuclei in breast cancer (BC) patients with different stages of the disease compared with their unaffected first degree relatives (FDR) and normal unrelated controls was investigated. Materials and Methods: The background and net micronucleus fre...

Background: Gemcitabine (2′, 2′-difluoro-2′- deoxycytidine, an analogue of deoxycytidine) is a relatively new drug with wide range of anti-cancer activity. In this study, radiosensitizing effects of gemcitabine was investigated on HeLa and MRC5 human originated cell lines under both chronically hypoxic and normoxic conditions using the micronucleus (MN) assay. Materials and Methods: F...

Moll (S Afr J Sci. 2023;119(1/2), Art. #12916) argues that we are not currently living in the Fourth Industrial Age (4IR). In this response to Moll, I contest Moll’s argument does correctly reflect understanding or definition of 4IR as presented pivotal texts leading global and South African advocates. believe that, had focused on initially by Schwab, is, around fusion technologies across digit...

Measurements of dissolved, ascorbate-reducible and total Mn by ICP-OES revealed significantly higher concentrations during estuarine turbidity maxima (ETM) events, compared with non-events in the Columbia River. Most probable number (MPN) counts of Mn-oxidizing or Mn-reducing heterotrophs were not statistically different from that of other heterotrophs (10³ -10⁴ cells ml⁻¹) when grown in define...

The amiloride-sensitive Na + /H + antiporter in defolliculated oocytes of Xenopus laevis was characterized by measurements of H Na + influx and apparent H + efflux. Uptake of ^Na"" was linear over a 90-min incubation period and was inhibited approximately 80% with 5xlO~moll~ amiloride. Amiloride-sensitive sodium uptake was reduced following collagenase treatment or oocyte aging. Ko 5 for amilor...

In this paper, the hemoglobin (Hb)-collagen microbelt modified electrode with three-dimensional configuration was fabricated via the electrospinning method. Direct electron transfer of the Hb immobilized into the electrospun collagen microbelts was greatly facilitated. The apparent heterogeneous electron transfer rate constant (k(s)) was calculated to be 270.6s⁻¹. The electrospun Hb-collagen mi...

In their study of a quartic integral, Boros and Moll discovered a special class of sequences, which is called the Boros–Moll sequences. In this paper, we consider the concavity and convexity of the Boros–Moll sequences {di(m)}i=0. We show that for any integer m > 6, there exist two positive integers t0(m) and t1(m) such that di(m)+di+2(m) > 2di+1(m) for i ∈ [0, t0(m)] ⋃ [t1(m),m−2] and di(m)+di...

Crackers are a popular food with an appreciable share of the consumer market. Fat is essential for sensory properties this product; however, high fat content associated health disorders. For reason, developing low-fat products same desirable attributes as corresponding full-fat ones priority industry. The objective study was to evaluate inclusion modified cassava starch substitute in crackers b...