نتایج جستجو برای: mlh3
تعداد نتایج: 113 فیلتر نتایج به سال:
Abstract Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction homologous requires the mismatch repair (MMR) genes MLH1 and MLH3 , essential in mice for fertility. Variants these can increase colorectal cancer risk, yet reproductive impacts are unclear. To determine if MLH1/3 single nucleotide polymorphisms (SNPs) human populations cou...
At the final step of homologous recombination, Holliday junction-containing joint molecules (JMs) are resolved to form crossover or noncrossover products. The enzymes responsible for JM resolution in vivo remain uncertain, but three distinct endonucleases capable of resolving JMs in vitro have been identified: Mus81-Mms4(EME1), Slx1-Slx4(BTBD12), and Yen1(GEN1). Using physical monitoring of rec...
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