Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran showed high reactivity to various chemical reagents. 24 products of the prepared compounds chosen tested in (mM) as respectable anticancer factors. The findings revealed that 3b, 6b, 8 widely effective against three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenoca...

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer (GC) cell lines and tumor tissues. Over-expression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted ...

PURPOSE A major problem when using the adenoviral vectors for gene therapy applications is thought to be related to low transduction efficiency in cancer cells or to side effects in normal cells. There is an urgent requirement to improve the specificity of gene delivery in the context of cancer gene therapy. EXPERIMENTAL DESIGN We constructed a genetically modified adenovirus incorporating an...