The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37 °C....

In this study we investigated resveratrol (trans-3,5,4'-trihydroxystilbene) solubilization with sodium 3α,12 α-dihydroxy-7-oxo-5 β-cholanoate (S7-OD) and sodium dodecyl sulfate (SDS). The investigation was aimed at determining whether large spherical micelles (SDS) or small longitudinal micelles (S7-OD) are more convenient for incorporation of resveratrol. Also, we studied resveratrol behavior ...

Structural transformations of vesicles to micelles that take place during the interaction of sodium dodecyl sulfate (SOS) with individual and mixed vesicles of phosphatidyl choline (PC) and phosphatidic acid (FA), have been studied by monitoring changes in optical density and in the concentration of free SOS monomer in the respective systems. Incorporation of the surfactant monomers (SOS) in th...

In this study, positively charged catanionic vesicles were fabricated from an ion pair amphiphile (IPA), hexadecyltrimethylammonium-dodecylsulfate (HTMA-DS), with the addition of a double-chained cationic surfactant, ditetradecyldimethylammonium bromide (DTDAB), and cholesterol by a mechanical dispersion process. The effects of the added cholesterol on physical stability of the catanionic vesic...

Critical micelle concentrations (CMCs) of cationic surfactant (alkyltrimethylammonium bromides, CnTABr, where n = 10, 12, 14, 16 and 18), and a bile salt sodium cholate (NaC) were determined from surface tension, conductance and dye solubilization methods, while of their equimolar mixtures from surface tension and dye solubilization methods. The interaction parameter (beta) obtained from analys...

We present a theoretical study of spatially modulated phases in self-assembled monolayers of mixed surfactants. We propose two models which are appropriate, respectively, for monolayers at a fluid-fluid interface and monolayers on a solid substrate. We show that in both cases, the molecular shape asymmetry, coupled with the local composition variation, can lead to spontaneous formation of perio...

Organic compounds with surfactant properties are commonly found in atmospheric aerosol particles. Surface activity can significantly influence the cloud droplet forming ability of these particles. We have studied the cloud droplet formation by two-component particles comprising one of the organic surfactants sodium octanoate, sodium decanoate, sodium dodecanoate, and sodium dodecyl sulfate, mix...