Food preservatives are unswervingly being used for prolonging the shelf life of food, often to increase aroma, taste and quality by food packaging industry. These pivotal in protecting from degradation deterioration micro-organisms. Two most commonly preservatives, viz. sodium nitrite (NaNO2) Monosodium glutamate (MSG) have been evaluated using root tips Allium cepa. Cytological studies plants ...

The actin cytoskeleton plays critical roles in numerous cellular events and functions, its spatiotemporal dynamics are maintained regulated by several cofactor proteins. MISP/Caprice is a recently reported actin-bundling protein that also involved the progression of mitosis. In this study, we investigated how actin-regulatory function MISP modulated phosphorylation. A series mutation studies de...

NuMA (Nuclear protein that associates with the Mitotic Apparatus) is a 235-kD intranuclear protein that accumulates at the pericentrosomal region of the mitotic spindle in vertebrate cells. To determine if NuMA plays an active role in organizing the microtubules at the polar region of the mitotic spindle, we have developed a cell free system for the assembly of mitotic asters derived from synch...

Following partial nephrectomy in juvenile metamorphosed Xenopus laevis the mitotic activity in the regenerating kidney reached its maximum on the 6th day and returned to its normal level by the 16th day. The mitotic activity was measured in the pronephros and epidermis of prefeeding Xenopus larvae (stage 38) at different intervals after their implantation into the lymph sacs of partially nephre...

The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 consecutive days in escalating dose cohorts, with skin and tumor biopsies obtai...

That certain hormones as well as neural agencies exert considerable effects upon the mitotic level of normal and regenerating tissues of Amphibia has been claimed from time to time. Denervation was stated to cause some measure of decrease in the mitotic activity of the regenerating tissues of adult newt(Singer and Craven, 1948). The mitotic responsiveness of epidermis of larval Amphibia to impl...

The effects of commercial formulations Viburnum opulus and Equisetum arvense extract on anti-cytotoxicity anti-genotoxicity were evaluated at the root tip Allium cepa L. Distilled water (negative control), dimethyl sulfoxide (DMSO), ethyl methane sulfonate (EMS, positive 5% 10% doses V. E. extracts applied for 24 48 hours. Cytotoxicity genotoxicity by calculating %mitotic index %chromosomal abe...

In this work, the cytotoxic and genotoxic influences of oxyfluorfen herbicide were surveyed by examining mitotic index, stages, chromosomal anomalies, micronucleus percentage, comet assay parameters on somatic cells Allium cepa. The roots treated with 0.2, 0.4, 0.8 1.6 ppm concentrations 12, 24 36 h. application periods. Mitotic index was noticeably diminished in each group when matched their c...

Syzygium laetum (Myrtaceae) is an endemic species of Western Ghats. The karyomorphology reported for the first time with mitotic chromosome number 2n=22. karyotype formula 2n=22=18m+4sm. a 2A type Stebbins category.

Disrupted passage through mitosis often leads to chromosome missegregation and the production of aneuploid progeny. Aneuploidy has long been recognized as a frequent characteristic of cancer cells and a possible cause of tumorigenesis. Drugs that target mitotic spindle assembly are frequently used to treat various types of human tumors. These lead to chronic mitotic arrest from sustained activa...