Fragile X-associated disorders are Repeat Expansion Diseases that result from expansion of a CGG/CCG-repeat in the FMR1 gene. Contractions of the repeat tract also occur, albeit at lower frequency. However, these contractions can potentially modulate disease symptoms or generate an allele with repeat numbers in the normal range. Little is known about the expansion mechanism and even less about ...

background: germline mutations in mmr genes are reported to be present in more than 70% of hnpcc cases. but, there is a paucity of data regarding the importance of defect of mmr system in the gastric cancer in general. so, in this study, we used ihc stain formlh1,msh2, pms2 andmsh6 to reveal profile ofmmr expression in patients with gastric cancer. materials and methods: this study was performe...

Technology scaling has led to growing concerns about reliability in microprocessors. Currently, fault tolerance techniques rely on explicit redundant execution for fault detection or recovery which incurs significant performance, power, or hardware overhead. This paper makes the observation that value predictability is a low-cost (albeit imperfect) form of program redundancy that can be exploit...

in this paper, optimization and control of a tubular reactor for thermal bulk post-polymerization of styrene have been investigated. by using the reactor mathematical model, static and dynamic simulations are carried out. based on an objective function including polymer conversion and polydispersity, reactor optimal temperature profile has been obtained. in the absence of model mismatch, desire...

the effects of physical, thermal and mechanical parameters on curing microthermal residual stresses are studied, based on the energy method, to present a theoretical solution for prediction of residual stress felds. a fnite element analysis is developed to compare the theoretical and numerical results together. there is found to be a good agreement between the results of the two methods. howeve...

In vitro, the methyl-directed mismatch repair system of Escherichia coli requires the single-strand exonuclease activity of either ExoI, ExoVII, or RecJ and possibly a fourth, unknown single-strand exonuclease. We have created the first precise null mutations in genes encoding ExoI and ExoVII and find that cells lacking these nucleases and RecJ perform mismatch repair in vivo normally such that...

In this paper, power-sharing management control on an AC islanded microgrid is investigated to achieve accurate reactive power sharing. The droop method primarily used manage the active and sharing among DGs in microgrid. However, line impedance mismatch causes unbalanced As a solution consensus-based adaptive virtual controller proposed, where consensus algorithm set mismatch; then correction ...

Mutations of chromosome replication genes can be one of the early events that promote genomic instability. Among genes that are involved in chromosomal replication, DNA polymerase alpha is essential for initiation of replication and lagging-strand synthesis. Here we examined the effect of two mutations in S. cerevisiae POL1, pol1-1 and pol1-17, on a microsatellite (GT)(16) tract. The pol1-17 mu...

Respiratory complications are critical events after sleeve lobectomy. A caliber mismatch is an important factor in wound healing at the anastomotic site. This study aimed to determine influence of mismatches on patients’ clinical courses We investigated 56 patients with primary lung cancer who underwent pulmonary resection end-to-end bronchoplasty. Anastomoses between main bronchus and segmenta...