congenital factor xiii deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in sistan and baluchestan province of iran. the discovery of promoter hypermethylation of numerous mirnas in human diseases has demonstrated an epigenetic mechanism for aberrant mirna expression. the present study has analyzed methylation and expression stat...

it was known that il-1β-induced rapid expression of mir-146a, which regulated the secretion of inflammatory chemokines in human a549 alveolar epithelial cells. however, little is known about the level of primary mir-146a and the downstream biogenesis of mir-146a in a549 cells. we examined the levels of primary mir-146a and mature mir-146a in a549 cells following treatment with pharmacological i...

Circulating microRNAs have been recognized as promising biomarkers for the detection of lung cancer. The objective of this study was to evaluate miR-10b, miR-1 and, miR-30a in the plasma samples of lung cancer patients to confirm any possible relevance in the early detection of lung cancer. Plasma samples from 47 non-small-cell lung cancer patients and 41 cancer-free subjects were evaluated for...

The daily environmental exposure of humans to plasticizers may adversely affect human health, representing a global issue. altered expression microRNAs (miRNAs) plays an important pathogenic role in plasticizers. This systematic review summarizes recent findings showing the modified miRNAs cancer due Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodolo...

objective(s):micrornas (mirnas) are a class of short rnas that control the biological processes including cell proliferation, apoptosis and development. aberrant expression of mirnas was determined in the different stages of tumor development and metastasis. to study the effect of silibinin on mirnas expression, we evaluated quantitative expression of mir-21 and mir-155 as two oncomirs and seve...

Sommario Il diabete mellito di tipo 2 (DMT2) è una malattia metabolica cronica eterogenea in costante aumento. In questa rassegna, al fine identificare un gruppo microRNA (miRNA) con potenziale applicazione clinica come biomarcatori per la diagnosi, prognosi e selezione terapie personalizzate i pazienti DMT2, abbiamo effettuato ricerca sistematica letteratura, identificando selezionando 10 miRN...