The aim of the present study was to examine the hypothesis that miR-33-5p attenuates morphine state-dependent (StD) memory via the µ opioid receptor by regulating cyclic AMP response element-binding protein (CREB). The effects of post-training morphine and morphine StD memory and their interaction with pre-test naloxone were evaluated using a single-trial inhibitory avoidance paradigm. Then, th...

MicroRNA (miRNA) expression profiling of colorectal cancer (CRC) are often inconsistent among different studies. To determine candidate miRNA biomarkers for CRC, we performed an integrative analysis of miRNA expression profiling compared CRC tissues and paired neighboring noncancerous colorectal tissues. Using robust rank aggregation method, we identified a miRNA set of 10 integrated-signature ...

MicroRNA are short and non-coding RNA, 18-25 nucleotides in length. They produced at the early stage of viral infection. The roles played by cellular miRNAs miRNA-mediated gene-silencing COVID-19 epidemic period is critical order to develop novel therapeutics. We analyzed SARS-CoV-2 Surface Glycoprotein (S) nucleotide sequence originating from India as well Iran, Australia, Germany, Italy, Russ...

It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression.  This study was performed to determine whether PEis associated with alterations in placental non-codingRNAs expression. MicroRNA(miR)-155-5p and long non-coding RN...

Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity mortality are increasing each year, due to lack of specific clinical symptoms early stage BC, diagnostic methods for breast cancer. Therefore, identifying an effective method BC has become urgent. Materials Methods: lesions with a histological diagnosis that were examined by ultrasonic elastography (UE...

Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues. Materials and Methods: The expression of miR-1297, miR-3191-5P, miR-4435, and miR-4465 were...

Predictive biomarkers for early diagnosis of prostate cancer are important its treatment. The functional microRNAs in the exosomes plasma and serum samples interest as stable non-invasive recurrence patients. present study aimed to clarify value exosomal miRNA-125a-5p miR-141-5p cancer. included 19 healthy individuals 31 In comparison levels controls, showed a slight increase patients (p=0.085)...