Universität Hamburg, Institut für Organische Chemie, Martin-Luther-King-Platz 6, D-2000 Hamburg 13, Bundesrepublik Deutschland Z. Naturforsch. 43c, 24-28 (1988); received August 18/October 30, 1987 Dedicated to Professor Ewald Sprecher on the occasion of his 65th birthday Lentinus lepideus, Lentideusether, Terrestrol, Fungal Sesquiterpenes, Fungal Fragrance Compounds The brown-rot fungus Lentin...

We examined the association between severity of disease in mastocytosis and skeletal manifestation and bone markers in 16 patients varying in extent of mastocytosis as determined by the urine excretion of methylimidazoleacetic acid. Both osteoporosis and osteosclerosis were found. Bone density in the hip was significantly higher (p < 0.05) in both men and women with an enhanced histamine metabo...

common carp, cyprinus carpio (l.) were blood-sampled after 0, 2, 6, 12, 24, 48 and 72 h fasting to find serum baseline levels. there was a significant difference in serum glucose, lactate, triglyceride and total protein but not cholesterol, albumin and calcium levels among the treatments. glucose levels increased with fasting tine and reached to a peak after 6 h. then, the glucose level decreas...

Several methods are known for the detection of traces of solvents in oil or paraffin. A gravimetric method (3) and a rapid colorimetrie method for the determination of residual solvents (4) are not sensitive enough. The same is true for the method developed by Eisdorf er &,Mehlenbacher (5) for the detenninatipn of trichloroethylene in plant oils after extraction with xylene. Rather sensitive de...

A rapid, sensitive and reproducible HPLC method was developed and validatedfor the analysis of amifostine (AMF) and/or its metabolite, WR-1065 inhuman plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (OPA) andUVdetection at 340 nm. The derivatized AMF and WR-1065 were eluted i...

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

BACKGROUND Vitamin D deficiency has been associated with a multitude of diseases, ranging from fractures to cancer. Nearly 99% of vitamin D metabolites are bound to proteins, altering the relationship between concentration and activity. METHODS & RESULTS Normalized concentrations were calculated and validated using published data regarding the correlation of 25-hydroxyvitamin D with bone mine...

Spinach (Spinacea oleracea) plants were grown either continuously on complete nutrient solutions or for 2 weeks on media deficient in phosphate or sulfate. To characterize leaf carbohydrate metabolism, levels of phosphorylated intermediates, activities of enzymes involved in photosynthetic carbon metabolism, contents of soluble and acid hydrolyzable sugars were measured in leaves differing in a...