BACKGROUND Recent studies have revealed that multiple sclerosis (MS) lesions have distinct microRNA (miRNA) expression profiles. miR-181 family members show altered expression in MS tissues although their participation in MS pathogenesis remains uncertain. Herein, we investigated the involvement of miR-181a and miR-181b in the pathogenesis of MS and its animal model, experimental autoimmune enc...

BACKGROUND MicroRNA-128 (miR-128) serves as a regulator by inducing cancer cell apoptosis, differentiation, the epithelial-to-mesenchymal transition process, and tumor growth by mediating different targets. NIMA-related kinase 2 (NEK2) is aberrantly expressed in lung cancer. The miR-128/NEK2 pathway has been reported to predict prognosis in colorectal cancer; however, the determination of a rel...

Transfection of human oral squamous carcinoma cells (clone E10) with mimics for unexpressed miR-20b or miR-363-5p, encoded by the miR-106a-363 cluster (miR-20b, miR-106a, miR-363-3p, or miR-363-5p), caused 40-50% decrease in proliferation. Transfection with mimics for miR-18a or miR-92a, encoded by the miR-17-92 cluster (all members being expressed in E10 cells), had no effect on proliferation....

In this paper we consider the problem of low power SpO2 sensors for acquiring Photoplethysmograph (PPG) signals. Most of the power in SpO2 sensors goes to lighting red and infra-red LEDs. We use compressive sensing to lower the amount of time LEDs are lit, thereby reducing the signal acquisition power. We observe power savings by a factor that is comparable to the sampling rate. At the receiver...

We have previously demonstrated that vibrotactile feedback of trunk motion significantly improves balance stability in individuals with vestibular deficits and older adults. Recently we have developed a Mobile Instrument for Motion Instruction and Correction (MIMIC) that enables an expert (i.e. physical therapist) to map his/her movements to a trainee (i.e. patient) in a hands-free fashion. MIM...

This study examined gender, socio-economic (SES), and ethnic group differences in academic performance (measured at 14 and 16 years) in a sample of 517 British pupils (mean age=16.5 years). White pupils outperformed their Black and Pakistani counterparts and high SES pupils consistently outperformed their low SES counterparts. Results from two Multiple Indicators Multiple Causes (MIMIC) models ...

We consider the MIMIc queue, where customers transfer to a critical state when their queueing (sojourn) time exceeds a random time. Lower and upper bounds for the distribution of the number of critical jobs are derived from two modifications of the original system. The two modified systems can be efficiently solved. Numerical calculations indicate the power of the approach.

This study of sibling resemblance in educational attainment seeks to determine whether the effect of family background on educational attainment differs according to family structure, birth order, and sex. In order to address these research problems, I analyze sibling data from both waves of the National Survey of Families and Households and use a form of the multiple indicator, multiple cause ...

This paper has two main goals. The first is to provide a framework for studying children well being utilising a capability approach. A list of capabilities for children in developing countries is drawn and its methodological justification is provided. The second aim is to suggest an econometric model to estimate child well being, utilising the list of capabilities provided in the first part of ...