Few first-rate biologists start their careers with only one ‘A-level’ (High School qualification) and a job in a copper wire factory. Fewer still go on to command a research budget of £250 million a year. But then Mike Dexter, who takes over this summer as director of the UK’s Wellcome Trust, the world’s biggest medical research charity, has always done things his own way. Dexter joins the Trus...

This paper shows how KARO (Knowledge Acquisition Environment with Reusable Ontoiogies) supports the development of the domain layer in MIKE (Model-based and Incremental Knowledge Engineering). KARO supplements the reuse of generic problem-solving methods at the task and inference layers in MIKE with a commonsense ontology at the domain layer. The intention is to make the development process eas...

John Michael Harrison (Mike Harrison) was born in London, England on February 2, 1915 and died on November 30, 2007 at his home in Brookline, MA. He received his early education at Stonyhurst College and then graduated from the Institution of Electrical Engineering, London, in 1942. He then obtained a postgraduate academic diploma in psychology from University College and Birkbeck College, Univ...