2014 The regions of stability of spherical, cylindrical, and lamellar phases of microemulsions are calculated within mean-field theory. In the cylindrical phase, thermal fluctuations determine a temperature dependent persistence length below which the cylinders are rigid (rod-like) and above which the cylinders are flexible (polymer-like). The length of the polymer-like chains depends on concen...

The available minoxidil formulations for topical application suffer with major drawback and requires repeated application. The present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel-systems (MEHs) for increased percutaneous penetration of minoxidil. Minoxidil microemulsions were developed by conventional titration method using oleic-acid as oil, twe...

Topical microemulsion of capsaicin without surfactant was developed in this study. In these systems, the oil phase was benzyl alcohol, and the cosurfactant was propylene glycol and ethanol. The drop-size of the systems was measured by dynamic light scattering method in order to distinguish true solution from microemulsion. The transdermal performance of the microemulsions was evaluated in vitro...

It has been shown previously that the binding of oxidized low-density lipoprotein (OxLDL) to resident mouse peritoneal macrophages can be inhibited (up to 70%) by the apoprotein B (apoB) isolated from OxLDL, suggesting that macrophage recognition of OxLDL is primarily dependent on its modified protein moiety. However, recent experiments have demonstrated that the lipids isolated from OxLDL and ...

The objective was to develop a microemulsion formulation for the transdermal delivery of testosterone. Microemulsion formulations were prepared using oleic acid as the oil phase, Tween20 as a surfactant, Transcutol as cosurfactant, and water. The microemulsions were characterized visually, with the polarizing microscope, and by dynamic light scattering. In addition, the pH, conductivity (sigma)...

Emulsions are commonly used in foods, pharmaceuticals and home-personal-care products. For emulsion based products, it is highly desirable to control the droplet size distribution to improve storage stability, appearance and in-use property. We report preparation of uniform-sized silicone oil microemulsions with different droplets diameters (1.4-40.0 μm) using SPG membrane emulsification techni...

The aim of the present study was to investigate the influence and the mechanisms of cineole and terpineol on the in-vitro transdermal delivery of huperzine A from microemulsions, and their potential synergistic effect on the permeation enhancement. The transdermal delivery of huperzine A from microemulsions with different concentrations of cineole and terpineol through the rat abdominal skin wa...

Microemulsions (μe) with water and a hydrophobic ionic liquid (IL) usually require 45-60 wt% surfactant to solubilize equal amounts of water and IL. To increase the efficiency we designed a new class of surfactants by combining a hydrophilic but IL-ophobic carbohydrate-based part with a hydrophobic but IL-ophilic IL-based part. These surfactants allow formulating microemulsions with 20 wt% surf...

The ability to induce morphological transitions in water-in-oil (w/o) and water-in-CO2 (w/c) microemulsions stabilized by a trichain anionic surfactant 1,4-bis(neopentyloxy)-3-(neopentyloxycarbonyl)-1,4-dioxobutane-2-sulfonate (TC14) with simple hydrotrope additives has been investigated. High-pressure small-angle neutron scattering (SANS) has revealed the addition of a small mole fraction of h...