The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light e...

We examined the phase behavior of various polyoxyethylene sorbitan fatty acid ester (polysorbates)/ethanol/isopropyl myristate (IPM)/150 mM NaCl solution (NaClaq) systems in order to prepare a microemulsion containing a low ratio of ethanol, which is more suitable for in vivo application. Using polyoxyethylene sorbitan trioleate (Tween 85), which has a large lipophilic moiety, as a surfactant c...

he photon correlation spectroscopy and small-angle X-ray scattering is used for study the mixture of C12E5 microemulsion with PEG in order to determine structure and dynamic of the system. Photon correlation spectroscopy experiment showed an exponential relaxation for pure C12E5 microemulsion that come from Brownian motion of oil nano-droplets in water. The shape of the relaxation changed with ...

The purpose of this review is to give an insight into the considerable potential of lecithin based nanocarriers. The lecithin microemulsion and closely related microemulsion based systems are currently of interest to pharmaceutical researchers. Conventional systems for topical delivery of drugs meet many hindrances like reduced permeation and entrapment efficiency. Lecithin nanocarriers with th...

OBJECTIVE The purpose of this study was to improve skin permeation of evodiamine and rutaecarpine for transdermal delivery with microemulsion as vehicle and investigate real-time cutaneous absorption of the drugs via in vivo microdialysis. METHODS Pseudoternary phase diagrams were constructed to evaluate microemulsion regions with various surfactants and cosurfactants. Nine formulations of oi...

Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and p...

Microemulsion science has provided a wide range of possibilities in materials fabrication. Here, we describe a novel approach to the synthesis of SrTiO3 nanoparticles of different shapes from a microemulsion. We show that the microemulsion structure plays a critical role in the shape of the nanoparticles, with diffusion-limited growth when normal or reverse micelles are present to nanocuboids w...

BACKGROUND The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. METHODS Various microemulsion vehicles were prepared using isopropyl myristate as an oil phase, polyoxyethylated castor oil (Cremophor(®) EL) as a surfactant, and polyethylene glycol 400 as a cosurfactant. In the optimum microemulsion gel...

correspondence: Qi shen school of Pharmacy, shanghai Jiao Tong University, Dongchuan road 800, shanghai 200240, People’s republic of china Tel +86 21 3420 4049 Fax +86 21 3420 4049 email [email protected] Background: The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations. Methods: Various microemulsion veh...

In the present work glipizide based microemulsion was developed and its usefulness as topical drug carrier system for the non-insulin dependent diabetes mellitus (NIDDM) was investigated. Microemulsion was prepared by water titration method using oleic acid as oil phase, tween-80 as surfactant and propylene glycol as co-surfactant. Menthol as a permeation enhancer was added to a final drug-load...