نتایج جستجو برای: microbeam

تعداد نتایج: 1126  

2014
Teruaki Konishi Masakazu Oikawa Noriyoshi Suya Alisa Kobayashi Takeshi Maeda Yukio Uchihori Yoshiyuki Shirakawa

There is continuing interest for the use of microbeam irradiation systems designed to deliver a defined number of charged particles on a single cell with a resolution of a few micrometers. Irradiation of an exact number of charged particles on a single cell means that the limitations of the Poisson distribution of the number of charged particles can be overcome. Moreover, microbeams are particu...

2012
N. Annabell N. Yagi K. Umetani C. Wong M. Geso

Synchrotron-generated microbeam radiotherapy holds great promise for future treatment, but the high dose gradients present conventional dosimetry with a challenge. Measuring the important peak-to-valley dose ratio (PVDR) of a microbeam-collimated synchrotron source requires both a dosimeter and an analysis method capable of exceptional spatial resolution. The PVDR is of great interest since it ...

Journal: :Neuro-oncology 2002
F Avraham Dilmanian Terry M Button Géraldine Le Duc Nan Zhong Louis A Peña Jennifer A L Smith Steve R Martinez Tigran Bacarian Jennifer Tammam Baorui Ren Peter M Farmer John Kalef-Ezra Peggy L Micca Marta M Nawrocky James A Niederer F Peter Recksiek Alexander Fuchs Eliot M Rosen

Radiotherapeutic doses for malignant gliomas are generally palliative because greater, supposedly curative doses would impart clinically unacceptable damage to nearby vital CNS tissues. To improve radiation treatment for human gliomas, we evaluated microbeam radiation therapy, which utilizes an array of parallel, microscopically thin (<100 microm) planar beams (microbeams) of synchrotron-genera...

In this article, the size effect on the dynamic behavior of a simply supported multi-cracked microbeam is studied based on the Modified Couple Stress Theory (MCST).  At first, based on MCST, the equivalent torsional stiffness spring for every open edge crack at its location is calculated; in this regard, the Stress Intensity Factor (SIF) is al...

2000
G. Morris

Introduction: Microbeam Radiation Therapy (MRT) research at both the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory and the European Synchrotron Radiation Facility (ESRF), Grenoble, France, has been primarily focused on the central nervous system (CNS). The aim of these research programs is to improve the treatment of neoplasms of the CNS. A standard and frequently u...

Journal: :International journal of radiation biology 1997
M Folkard B Vojnovic K M Prise A G Bowey R J Locke G Schettino B D Michael

Charged-particle microbeams provide a unique opportunity to control precisely, the dose to individual cells and the localization of dose within the cell. The Gray Laboratory is now routinely operating a charged-particle microbeam capable of delivering targeted and counted particles to individual cells, at a dose-rate sufficient to permit a number of single-cell assays of radiation damage to be ...

2012
K. Aikoh A. Tohki T. Matsui A. Iwase T. Satoh K. Takano M. Kohka Y. Saitoh T. Kamiya T. Ohkochi M. Kotsugi T. Nakamura T. Kinoshita

FeRh thin films were irradiated with a 10 MeV iodine ion microbeam to produce micrometre-scale ferromagnetic microstructures by modifying the local magnetic character from antiferromagnetism to ferromagnetism using ion-microbeam irradiation. Two-dimensional magnetic dot arrays of dimensions ∼2 µm × 4 µm as well as 10 µm × 10 µm were successfully produced on the FeRh surface, which was confirmed...

Journal: :Journal of radiation research 2009
Hongning Zhou Mei Hong Yunfei Chai Tom K Hei

The prevailing dogma for radiation biology is that genotoxic effects of ionizing radiation such as mutations and carcinogenesis are attributed mainly to direct damage to the nucleus. However, with the development of microbeam that can target precise positions inside the cells, accumulating evidences have shown that energy deposit by radiation in nuclear DNA is not required to trigger the damage...

Journal: :Developmental biology 1974
G McBride J LaBounty J Adams M Berns

The relationship of seta-bearing cells of Coleochaete scutata (Chlorophyta Ulotrichales) to normal growth and development of the thallus was investigated using laser microbeam irradiation. When all of the seta-bearing cells of a thallus, except the small primary seta-bearing cell, were destroyed by laser microbeam irradiation, the thallus grew as rapidly as thalli that had received no radiation...

Journal: :Radiation Protection Dosimetry 2015

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