From a policy standpoint, a growing elderly population has become a challenge to our society. However, we maintain we can be moderately optimistic, because cognitive impairment, or worse, dementia, are not always caused by Alzheimer’s disease or are the consequence of major ischemic or haemorrhagic stroke. They are often due to micro-infarcts and/or micro-haemorrhages ("mini-strokes") at the le...

Esophageal cancer is a disease with increasing frequency in both esophageal squamous cell carcinoma and especially for esophageal adenocarcinoma, according to statistics representing the sixth leading cause of death from malignancy in the world. The study group included 24 cases of squamous cell carcinoma, from which we collected tissue samples histological stained with hematoxylin–eosin and sp...

To understand the pathology of myocardial ischaemia detailed knowledge of the anatomy and physiology of the coronary arterial tree is required. The anatomy of the major coronary arteries running on the epicardial surface of the heart has been common knowledge for years. The equally important micro-anatomy of vessels within the myocardium has been neglected along with the physiology of intramyoc...

A concept for monitoring of maritime traffic by micro-satellites has been studied at FFI [1]. The concept is based on localization of maritime vessels by passive detection of their X-band navigation radar (3 cm wavelength), and subsequent direction finding and determination of the geographic position. A Phase-A study [3] on the utilization of this concept, for monitoring of the maritime traffic...

OBJECTIVE The goal of this study was to determine if an iodinated, liposomal contrast agent could be used for high-resolution, micro-CT of low-contrast, small-size vessels in a murine model. MATERIALS AND METHODS A second-generation, liposomal blood pool contrast agent encapsulating a high concentration of iodine (83-105 mg I/mL) was evaluated. A total of five mice weighing between 20 and 28 ...

BACKGROUND Experimental hypercholesterolemia (HC) impairs intramyocardial microvascular function. However, whether this is associated with alterations in microvascular architecture remained unknown. Using a novel 3D micro-CT scanner, we tested the hypothesis that HC is associated with an alteration in the microvascular architecture. METHODS AND RESULTS Pigs were euthanized after 12 weeks of e...

Tumour endothelial marker-8 (TEM-8) belongs to a family of endothelial markers that are raised during tumour angiogenesis. We have recently reported aberrant expression of TEMs at the mRNA level in human breast cancer. This study sought to examine the level of TEM-8 expression at the protein and mRNA level in human breast cancer tissue, and in a panel of human breast cancer cell lines. We also ...

Abstract In tumors, angiogenesis (conformation of a new vasculature from another primal one) is produced with the releasing tumor angiogenic factors hypoxic cells. These substances are distributed around micro-environment by diffusion. When they reach blood vessel bed, sprouting and branching micro-vascular network produced. capillaries will supply oxygen to cells so that their state overcome. ...

Shape memory polymers (SMPs) as a relatively new class of smart materials have gained increasing attention in academic research and industrial developments (e.g., biomedical engineering, aerospace, robotics, automotive industries, textiles). SMPs can switch their shape, stiffness, size, structure upon being exposed to external stimuli. Electrospinning technique endow with micro-/nanocharacteris...

I t is generally accepted that the role of angio-genesis in the progression of human solid tumors was originally postulated by Folkman in 1971. 1 The central component in this revolutionary paradigm was that tumor cells undergo an angiogenic switch and generate vasculariza-tion intimate to the tumor. 2 Prior to this switch, tumors are less than 3 mm 3 and thus this new vascularization allows th...