conclusions these outcomes support our theory that rapamycin increases oxidative stress in mcf-7 and mda mb-231 cells but also shows high levels of antioxidant effects, which probably limit the effects of the rapamycin on the same issue in the clinic. methods the mcf-7 and mda mb-231 cell lines were cultivated and treated with rapamycin for 72 hours. the viability of the cells was determined us...

extracts derived from viscum album have been shown to kill cancer cells in vitro. some studies have noted that different species of this plant collected from around the world displayed cytotoxic effects in different extents. in the present study, we evaluated the effects of iranian mistletoe extracts on five cancer cell lines. plants growing on hornbeam tree (carpinus betulus) were collected, a...

Authors’ Affi liations: 1 Divisions of Molecular Medicine and Genetics, Department of Internal Medicine, and 2 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan Corresponding Author: Jun-Lin Guan, University of Michigan Medical School, 3027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109. Phone: 734-615-4936; Fax: 734-763-1166; E-mail: jl...

Authors’ Affi liations: 1 Divisions of Molecular Medicine and Genetics, Department of Internal Medicine, and 2 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan Corresponding Author: Jun-Lin Guan, University of Michigan Medical School, 3027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109. Phone: 734-615-4936; Fax: 734-763-1166; E-mail: jl...

Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 981 95 1). G. G., S. DI; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 Ii. G. G., S. Di; Division of Epidemiology, Michigan Cancer Foundation, Detroit, Michigan 48201 JR. K. 5.1; Department of C...

background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...

T rastuzumab (herceptin) is approved for the treatment of breast cancer patients whose tumors express a high level of the drug's target her2/neu. yet at least two retrospective analyses of prospec­ tive trials suggest the drug may also improve survival in women with early breast cancer whose tumors do not overexpress her2/ neu. A plausible mechanism for those con­ troversial observations has be...

objective(s): many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. material and methods:metabolism of c...

Background: Breast cancer is a leading cause of cancer death for women. Disparities in patient survival should be investigated to improve treatment and prevention methods. The SEER cancer registries have collected most of the breast cancer data for Michigan and California compared to other states. It is important to discern whether there are racial and ethnic differences in age of diagnosis and...

background & aim:breast cancer is the second most common cancer in women after lung cancer. given that the herbal ingredients are used for centuries to treat cancer,the aim of this study was to determine the cytotoxic effect of hydroalcholic extract from thymus daenesiscelak on mcf-7 cancer cells line. experimental: breast cancer cells mcf-7 and natural fibroblast cells were cultured in dmem me...