Research Objective This study was aimed to determine the main ingredients of Huajie Xiaoliu Formula (HJF) and investigate anti-colon cancer effect its combination with Tegafur, Gimeracil, Oteracil Potassium Capsules (S-1) in vivo as well preliminarily explore possible mechanism. Materials Methods The chemical composition HJF determined by ultra-high performance liquid chromatography quadrupole ...

Matrix metalloproteinases (MMPs) foster cellular invasion by disrupting extracellular matrix barriers and thereby facilitate tumor development. MMPs are synthesized by both cancer cells and adjacent stromal cells, primarily macrophages. The production of macrophages is regulated by colony-stimulating factor-1 (CSF-1). Tissue CSF-1 expression increased significantly in embryonic and colon cancer...

the most common metastatic sites for colorectal carcinomas include the liver, lungs, brain, bones and peritoneal surfaces. in this report, a case of sigmoid colon carcinoma presented with cervical lymphadenopathy was detected with the help of pet/ct. a 57 year-old male presented with a complaint of swelling on the left side of his neck. ultrasonographic examination of the neck revealed three hy...

Even before its advent in 1999; Pioglitazone as well as other members of the thiazolidinediones group have been questioned for a relationship with colon carcinoma in mice; an adverse effect that was subsequently evidenced to occur also in some types of human colon cancer cells [2,3]. Similarly, preclinical studies have also showed that bladder tumors were observed in male rats receiving doses o...

This paper presents four cases of abnormal soft tissue activity in the bone scan of patients with different lesions (lung inflammatory pseudotumor, pulmonary fibrosis, pulmonary metastatic osteosarcoma and metastatic hepatic carcinoma of colon).

DMP 840, a novel bis-naphthalimide, was evaluated for antitumor efficacy in several tumor models in mice. As measured by a tumor growth inhibition assay, i.v. administration of DMP 840 to athymic nude mice at doses at or below the maximum tolerated dose resulted in curative activity against four human solid tumor xenografts, MX-1 mammary carcinoma, CX-1 and DLD-2 colon adenocarcinomas, and LX-1...

Recombinant adenoviral mediated delivery of suicide and cytokine genes has been investigated as a treatment for hepatic metastases of colon carcinoma in mice. Liver tumors were established by intrahepatic implantation of a poorly immunogenic colon carcinoma cell line (MCA-26), which is syngeneic in BALB/c mice. Intratumoral transfer of the herpes simplex virus type 1 thymidine kinase (HSV-tk) a...

Background: The SALL4/Sall4 is constitutively expressed in human and mice. SALL4 mRNA could be used as a marker for the diagnosis of different types of cancers. On the other hand, chrysin has diverse biological properties. Objectives: In the present study, the effect of the chrysin was investigated on the CT26 colon cancer in vitro and in vivo. Furthermore, the expression levels of the stem cel...

Hybrid liposomes (HLs) composed of vesicular and micellar surfactants have inhibitory effects on the growth of tumor cells in vitro and in vivo. Successful clinical chemotherapy with drug-free HLs to patient with lymphoma has been reported after approval by the Committe of Bioethics. However, the therapeutic effects of HLs on the metastasis of colon carcinoma cells have not yet been elucidated....

The purpose of these studies was to determine the possible mechanisms responsible for the therapeutic effects of systemic administration of 5-fluorouracil (FUra) and gamma-interferon on disseminated human colon cancer. We used several human carcinoma cell lines that were established from different surgical specimens. Some lines were selected in nude mice for increased metastatic potential, and ...