We have investigated the dose-effect relationship of neostigmine in antagonizing vecuronium-induced neuromuscular block with and without magnesium sulphate (MgSO4) pretreatment. Neuromuscular block was assessed by electromyography with train-of-four (TOF) stimulation. First, we determined neostigmine-induced recovery in patients pretreated with MgSO4 (group A) or saline (group B) (n = 12 each)....

The platelet count, mean platelet volume, and other hematological parameters were compared in blood samples anticoagulated with MgSO4 and EDTA. A total of 15 samples were taken, and the platelet counts were observed to be significantly high in MgSO4-anticoagulated blood samples ranging from 53 × 103 to 499 × 103/μL, whereas in EDTA-anticoagulated blood samples, the counts ranged from 10 × 103 t...

BACKGROUND Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32-34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP) was a multifaceted knowledge translation (KT) strategy for this practice. METHODS The KT strategy included national clinical practice guidelines, a n...

OBJECTIVE Recent studies have shown the positive effect of magnesium sulphate (MgSO4) on pain reduction and postoperative analgesic requirements in patients undergoing surgery. We assessed the effect of MgSO4 on intra-operative and postoperative analgesic requirements in patients undergoing lower abdominal gynecological laparotomy. MATERIALS AND METHODS This randomized clinical trial was cond...

Eclampsia is a hypertensive disorder of pregnancy and a leading cause of maternal death. The primary explanation for eclampsia is that it represents a form of hypertensive encephalopathy (HTE) with neurological symptoms including headaches, nausea, vomiting, visual disturbances, and seizures. The etiology of HTE involves an acute increase in arterial blood pressure that exceeds the autoregulato...

Magnesium is the fourth most abundant cation in the body and the second most abundant cation in intracellular fluid. Magnesium plays an important role in numerous biological functions. In the present study we investigated the effect of magnesium sulfate (MgSO4) on histological abnormalities induced by bile duct ligation in male Wistar rats. The effects of 28-day oral administration of MgSO4 (at...

Eclampsia is a hypertensive disorder of pregnancy and a leading cause of maternal death. The primary explanation for eclampsia is that it represents a form of hypertensive encephalopathy (HTE) with neurological symptoms including headaches, nausea, vomiting, visual disturbances, and seizures. The etiology of HTE involves an acute increase in arterial blood pressure that exceeds the autoregulato...

Introducción: La neuroprotección farmacológica es utilizada en el periodo antenatal para ayudar a disminuir riesgo de parálisis cerebral o disfunciones motoras recién nacido (RN). El sulfato magnesio (MgSO4) gran utilidad por los beneficios que aporta como tocolítico, neuroprotector fetal prematuros menores 32 semanas y manejo la preeclampsia. Sin embargo, durante su uso se han registrado efect...

BACKGROUND Regional anesthesia is known to significantly impair thermoregulation and predispose patients to hypothermia. We hypothesized that the addition of an intrathecal injection of magnesium sulfate (MgSO4) to bupivacaine would improve perioperative shivering in female patients undergoing elective caesarean section. METHODS In a block-randomized, double-blinded, controlled trial 72 patie...