UNLABELLED L-3-[123I]iodo-alpha-methyl-tyrosine (IMT) is a modified amino acid that is avidly taken up by many tumors. Uptake is based on the increased transmembrane transport of amino acids in malignancies. IMT is the only amino acid tracer suitable for SPECT. The aim of this study was to determine the feasibility of IMT SPECT in the detection, staging, and treatment evaluation of non-small ce...

UNLABELLED System L amino acid transport is increased in various types of cancer. The tracer 123I-2-iodotyrosine (2IT), which is accumulated via system L, could thus serve to allow visualization of cancer in vivo. Here, we studied the transport of 125I-2IT by h4F2hc-hLAT1, the major transporter subserving system L in growing cells, using the Xenopus laevis oocyte expression system. We compared ...

The catecholamines, dopamine, norepinephrine, and epinephrine, have been found in brain regions associated with cardiovascular regulation. We wished to determine whether central catecholaminergic neurons participate in the reflex alterations of cardiac autonomic nerve traffic associated with acute myocardial ischemia. Five groups of rats treated with a-methyltyrosine, an inhibitor of catecholam...

OBJECTIVES To compare L-3-[18F]-fluoro-a-methyltyrosine (FMT)-positron emission tomography (PET) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG)-PET in the differential diagnosis of maxillofacial tumors. METHODS This study included 36 patients (16 males, 20 females; 31-90 years old) with untreated malignant tumors (34 squamous cell carcinoma, one mucoepidermoid carcinoma, one rhabdomyosarcoma) and...

Cholinergic Properties of the Relay Junctions of the Primary Afferent Pathway. D. T. FRAZIER AND L. L. BOYARSKY 1 Monoamine Levels and Neuronal Degeneration in Rat Brain following Lateral Hypothalamic Lesions. ROBERT Y. Moons AND ALFRED HELLER 12 Localization of Tritiated Serotonin in Rat Brain by Electron-Microscopic Autoradiography. GEORGE K. AGHAJANIAN AND FLOYD E. BLOOM 23 The Effect of Dru...

With the increasing clinical application of FDG PET, interest in metabolic imaging in general is growing among clinicians. The reasons for the great impact that FDG PET is currently making in oncologic diagnostics are (a) the exceptionally high uptake and trapping of FDG in malignant cells and (b) the technical performance of PET systems with high resolution and counting efficiency. These 2 fac...

UNLABELLED The aim of this study was to evaluate the prognostic value of SPECT imaging using the amino acid analog 3-[(123)I]iodo-L-alpha-methyltyrosine (IMT) in patients with gliomas. METHODS One hundred fourteen consecutive patients with newly diagnosed gliomas were examined by IMT SPECT (low-grade glioma, n = 12; anaplastic astrocytoma or oligodendroglioma, n = 46; glioblastoma, n = 56). S...

The Neuropeptide Y (NPY) is a peptide of 36 amino acids, similar to the peptide YY (PYY) and to the pancreatic polypeptides (PP). At first, separated from the pig brain, the NPY is well-distributed in the mammals at the level of the central and peripheric nervous system. This neurotransmitter is present in strong concentrations in the nervous fiber of the brain, but equally as strong in the hea...

The composition of an evolving arterial thrombus may be a determinant of how effectively pharmacologic agents prevent reocclusion after initially successful thrombolysis. In this study, reoccluding plateletor fibrin-rich thrombi as delineated by scanning electron microscopy were produced selectively in the femoral arteries of dogs with the use of electrically induced vascular injury or implanta...

The composition of an evolving arterial thrombus may be a determinant of how effectively pharmacologic agents prevent reocclusion after initially successful thrombolysis. In this study, reoccluding platelet- or fibrin-rich thrombi as delineated by scanning electron microscopy were produced selectively in the femoral arteries of dogs with the use of electrically induced vascular injury or implan...