Male factor infertility affects 30--40% of the subfertile couples worldwide and that poses a significant medical social issue. Different strategies are developed to increase fertilization potential male gametes during procedures assisted reproduction. One these approaches is addition biologically active molecules, which help stimulate motility spermatozoa. In current investigation, we analysed ...

In the literature, it remains uncertain whether methylxanthines inhibit hypoxic pulmonary vasoconstriction. We examined the effects of theophylline and of S 9795, a new methylxanthine derivative, on multipoint mean pulmonary arterial pressure (Ppa)/cardiac index (Q) relationships in 31 intact dogs, ventilated alternately in hyperoxia (fraction of inspired oxygen, FIO2 0.4) and in hypoxia (FIO2 ...

Methylxanthines enhance lethality of alkylating agents in human cancer cells, a phenomenon attributed to the prevention of DNA repair. Pentoxifylline is a nontoxic methylxanthine, used clinically for claudication. Using human cancer cells in culture or in a mouse xenograft model, we studied combination treatments with alkylating agents and pentoxifylline or other methylxanthines. With human bla...

We have recently presented a hypothesis of the mechanism by which the mutation rate of Escherichia coli is increased in the presence of methylxanthines (1). It was suggested that methylxanthines partially inhibit the synthesis of some nucleic acid intermediates, thus causing an increased probability for the utilization of a substitute compound in the synthesis of the specific polynucleotide tha...

The striking analogies between the processes regulating secretion and contraction led Douglas and Rubin [l] to introduce the term ‘stimulus-secretion coupling’ to parallel the concept of ‘excitation-contraction coupling’ proposed earlier by Sandow [2] . The effects of several alkaloids on muscle contraction have long been recognized and their site and mechanism of action extensively studied [3]...