Polymeric microparticles have been used widely for sustained drug delivery. Current methods of microparticle production can be improved by making homogeneous particles in size and shape, increasing the drug loading, and controlling the initial burst release. In the current study, the hydrogel template method was used to produce homogeneous poly(lactide-co-glycolide) (PLGA) microparticles and to...

CAMERON, C. M. , BRETT, 0. L. & FULS, W. J. P., 1974. The effect of immunosuppression on the development of immunity to fowl typhoid. Onderstepoort J. vet. Res. 41 (1), 15-22 (1974). Chickens which were given cyclophosphamide during the first three to five days of life showed a marked depression in their humoral antibody response to sheep erythrocytes and Bmcel/a antigen. Thei r ability to deve...

Background and Objective: Pneumocystis pneumonia (PCP) has been historically the most prevalent opportunistic infection in patients infected with the human immunodeficiency virus. Culture of the organism has not been faced with suitable success in artificial media, while various results have been reported for cell culture media. The aim of this study was proliferation of Pneumocystis carinii on...

BACKGROUND Low Back Pain (LBP) and radicular leg pain (RLP) after lumbar disc surgery are great challenges that prevent patients and neurosurgeons in making a surgical decision. By spinal anesthesia, LBP and RLP diminish up to 2 to 3 hours postoperatively. The aim of this study was to determine the effect of impregnated epidural adipose tissue (EAT) with bupivacaine or methylprednisolone acetat...

In a comparative study concerning the effect of corticosteroids on host resistance to infections, five compounds were found to decrease host resistance, while three did not have this property, although all eight compounds were highly antiinflammatory. The compounds capable of decreasing host resistance were (I) hydrocortisone acetate; (III) 9alpha-fluoro, 16alpha-methylprednisolone acetate; (IV...

Purpose: Inflammatory bowel disease (IBD) is a chronic, relapsing and often life-long disorder. The best way to tackle IBD is to develop a site targeted drug delivery. Methylprednisolone is a potent anti-inflammatory steroid. The relative potency of methylprednisolone to hydrocortisone is at least four is to one. The aim of the present research was to develop a colon targeted drug delivery for ...

are rapidly dispersed. The microcrystals may themselves induce an acute inflanmmatory response (a,s in gout) either in the joint or soft tissues. Occasionally this may be intense and prolonged for several days. Numerous preparations are available, but in practice it is useful to have available two or three preparations varing in strength and length of action. The long-acting agents tend to caus...