A 55-year-old, previously healthy woman, presented with frequent headaches. She had no neurological disturbances, but had a positive family history; her father died from stroke. Magnetic resonance imaging showed brain infarction; therefore detailed diagnostic evaluation of thrombophilia markers and genetic testing were performed. The patient was found to be homozy- gous for the C677T mutation o...

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction (MI). Single nucleotide at any one amino acid sequences can result diseased state. A single gene exhibit genetic more than position giving rise to different variants. angiotensinogen (AGT) M235T, AGT T174M, angiotensin-1-converting enzyme (ACE) I/D, endothelial nitric oxide synthase (eNOS), methyl...

background: to assess whether the c677t and a1298c mutations in the methylenetetrahydrofolate reductase (mther) gene are associated with recurrent abortion (ra), we determined the frequencies of the t677 and c1298 mutations in patients and controls. materials and methods: mutations were determined by a rflp-pcr method in 53 patients and 61 matched controls. results: the frequencies of t alleles...