The geometries of various tautomers and isomers of 2-methylamino-2-imidazoline, 2-methylamino-2oxazoline, 2-methylamino-2-thiazoline, 2-phenylamino-2-imidazoline, 2-phenylamino-2-oxazoline, and 2-phenylamino-2-thiazoline have been studied using the Becke3LYP/6–31+G(d,p) DFT, ONIOM(Becke3LYP/6–31+G(d,p):HF/3–21G∗) and ONIOM(Becke3LYP/6–31+G(d,p):AM1) methods. The optimized geometries indicate th...

R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.

Using "chemically misacylated AMP" which is photogeneratable, tRNA can be enzymatically acylated with N-methylamino acids in an efficiency comparable to that of the corresponding natural aminoacylation process with amino acids.

S-adenosyl-l-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. Derivatives of an irreversible inhibitor of this enzyme, 5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine (MDL73811), have been developed with improved pharmacokinetic profi...

A series of dimetallic and monometallic Cp*Ir(III) complexes bearing naphthalene-diimide-decorated N-heterocyclic carbene/pyridine [NDI-(NHC-pyridine)] ligands were prepared characterized. The show a C,C-chelating coordination the NHC-pyridine ligand, with pyridine ring ligand bound to metal via cyclometallation rather than by its nitrogen atom, although atom could be achieved subjecting one re...

1. Inhibition by pyridine of reduction of NAD by ethanol in the presence of yeast alcohol dehydrogenase was studied at 25 degrees in 60mm-glycine buffer (K(+), pH9.3). 2. The apparent Michaelis constant for ethanol increases linearly and that for NAD increases non-linearly with pyridine concentration. 3. Rates, v, observed in the presence of pyridine are lower than the values calculated from th...

Overview to Pyridine Nucleotides Review Series [Circ Res. 2012;111:604–610.] Regulation of Cell Survival and Death by Pyridine Nucleotides [Circ Res. 2012;111:611–627.] Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism [Circ Res. 2012;111:628–641.] Sirtuins and Pyridine Nucleotides [Circ Res. 2012;111:642–656.] Sirtuins and Pyridine Nucleotides [Circ Res. 2012;111:642-656.] Regu...