Optic neuritis an inflammatory disorder of the optic nerve inflammation is usually in young’s with symptoms of eye pain and vision loss that occurs is a common symptom of MS. Optic neuritis is one of the first symptoms of MS that observable into disorders in white matter of cerebral cortex. The risk of MS in patients with optic neuritis during 2 years 20% in 15 years, 45-80% is calculated...

1. Oxidative decarboxylation of 4-methyl-2-oxopentanoate (2-oxoisocaproate) by mitochondria of rat skeletal muscle showed biphasic kinetics. Two apparent Km values of 9.1 micronM and 0.78 mM were established. In broken mitochondria the rate of oxidation was lower and only the higher apparent Km value was found. 2. Isovalerylcarnitine inhibited 4-methyl-2-oxopentanoate oxidation in the presence ...

AIM Spinal Cord Injury (SCI) is routinely treated with standardized methyl prednisolone sodium succinate (MPSS) dose, so it is reassuring to find its effects on liver. We also evaluated the effects of albumin and immunoglobulin G (Ig G) therapies on liver if they are used in case of experimental SCI. MATERIAL AND METHODS The rats were allocated into six groups as control, trauma, vehicle, MPS...

I was pleased to read Berber et al’s 50 year-old patient with Evans syndrome which was published as a Letter to The Editor in the recent issue of the Journal of Turgut Ozal Medical Center (2013;20(3):289-290). But, it was surprised to me that mega dose methyl prednisolone (MDMP) treatment was not brought to attention which had been successfully used for these patients first time from our countr...

Background: The effects of high dose steroids for the treatment of methanol optic neuropathy was evaluated in this study. Methods: In an interventional case series, 9 patients with a history of sudden visual loss after an ingestion of homemade alcoholic beverages were included in the study. The patients received 250 mg intravenous methyl prednisolone every 6 hours for 4 days continued with oral...

This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects release retardant on in vitro drug release. is β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, Anti Angina. has 48% oral bioavailability due limited absorption from lower gastrointestinal tract. The tablets were designed increase stomach retention, prolong release,...

Using Methyl Prednisolone in a Patient with Intracranial Hemorrhage Clopidogrel and ticlopidine are agents that irreversibly inhibit adenosine diphosphate (ADP)–induced platelet aggregation. Interaction of ADP with the P2Y1 receptor of the platelet induces platelet shape change, reversible aggregation, initial glycoprotein IIb/IIIa activation, phospholipase C activation, and calcium flux. Thien...

Treatment of Escherichia coli with colicin Ia leads to an inhibition in the active transport of exogenously supplied proline, thiomethyl-beta-D-galactoside and potassium ion. Furthermore, the addition of colicin Ia to cells preloaded with these substances leads to their almost immediate efflux. In contrast, colicin tia treatment enhances by as much as 10-fold the level of accumulation of alpha-...