We report successful use of methyl-prednisolone in a 21-month old child with ARDS that did not improve with conventional therapy. The child improved and could be extubated after 10 days of methylprednisolone therapy. Subsequently, the child was weaned off supplementary oxygen. Methylprednisolone appeared to be safe and effective in a child with unresolving ARDS.

We report a case of a 42-year-old patient who presented with Wegener's granulomatosis complicated by pulmonary renal syndrome, i.e., diffuse alveolar haemorrhage and rapidly progressive crescentic glomerulonephritis. The patient was treated with plasmapheresis and immunosuppressive drugs--intravenous cyclophosphamide and methyl prednisolone. The clinical, haematological and biochemical paramete...

In this prospective study the effect of low dose methylprednisolone succinate (10mg/kg) on the incidence of fat embolism syndrome and isolated arterial hypoxemia in 99 patients with long bone fracture (52 control and 47 steroid-trated subjects) was studied. Frequency of fractures among the selected patients was as follows: femoral fracture 52.5%, tibial fracture 36.4%, both femoral and tibial f...

Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is an inflammatory demyelinating disorder caused by the development of immunoglobulin G autoantibody targeting MOG, which expressed exclusively on outer surface myelin sheath and plasma membrane oligodendrocyte. MOGAD can present in different clinical spectrum including acute disseminated encephalomyelitis (ADEM), optic neu...

Glucocorticoids are widely prescribed to treat autoimmune and inflammatory diseases. Although they are extremely potent, their utility in clinical practice is limited by a variety of adverse side effects. Development of compounds that retain the potent immunomodulating and anti-inflammatory properties of classic glucocorticoids while exhibiting reduced adverse actions is therefore a priority. U...

During the past few years a concerted effort has been made to develop synthetic derivatives of hydrocortisone and cortisone which would retain their anti-inflammatory activity but would be devoid of certain of their unwanted physiologic effects. Hope that analogues with enhanced therapeutic indices could be synthesized has stemmed from the knowledge that several properties of the naturally occu...