characterized by degeneration of nigro-striatal dopaminergic neurons and reduction in the level of dopamine in this area. Since the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) could induce parkinsonism in humans, 1,2,3,4-tetrahydroisoquinoline (TIQ) derivatives have been considered as candidate endogenous causative factors of idiopathic Parkinson’s disease (PD), because o...

Some aromatic aldehydes are subjected to react with urea (or thiourea) and acetyl acetone in a one-pot Biginelli-type cyclocondensation reaction to give 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro-pyrimidines 2a-j. Aldehydes with ortho-hydroxy substituent namely salicylaldehyde and 2-hydroxy-3-methoxybenzaldehyde undergo Michael-type addition of the hydroxyl-proton to the C5−C6 double bond of t...

Selected nemadectins (formerly LL-F28249 series) have been fed to a panel of microorganisms with the aim of generating new derivatives. In addition to products resulting from the oxidation of the terminal methyl group (C-29), a unique phosphorylated nemadectin was isolated. The phosphate group was determined to be at C-23 by HMBC between phosphorus and H-23. Milbemycin or nemadectin derivatives...

A diphenylmethane model compound (2,2¢-methylenebis[6-methoxy-4-methylphenol]) and residual kraft lignin were treated with alkaline hydrogen peroxide. Kinetic data for the disappearance of the model and the diphenylmethane structures in the residual lignin was collected. The activation energies for the degradation were found to be similar (54 ± 11 kJ mol–1 for the model and 58 ± 5 kJ mol–1 for ...

abstract application of chemicals which activate plant defense mechanisms before pathogen attack without environmental side effects of protective chemical agents have stimulated great deal of researches in this area. one of the important crops in the world is tomato and recently recognized as a model plant for plant-pathogen interactions. tomato early blight is one of the most devastating disea...

The title compound, C(14)H(13)N(3)O(3)·H(2)O, was prepared by the reaction of 4-methoxy-salicylaldehyde and isonicotinohydrazide in ethanol. The Schiff base mol-ecule is not planar and has an E configuration with respect to the methyl-idene unit. The dihedral angle between the benzene and pyridine rings is 36.8 (2)°. In the mol-ecule there is an intra-molecular O-H⋯N hydrogen bond involving the...

CYP1A1 and CYP1B1 are two extrahepatic enzymes that have been implicated in carcinogenesis and cancer progression. Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of dietary chemoprevention. In parallel, recent studies have documented the ability of CYP1 enzymes to selectively metabolize ...

a series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. the stereochemistry of 1,4-dihydr...

We previously reported that (Z)-2-(4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl)methoxy]benzyloxyimino)-2-(4-phenoxyphenyl)acetic acid (3) showed potent glucose and lipid lowering effects in genetically obese and diabetic mice, KKA(y). This compound also showed transcriptional activity for peroxisome proliferator-activated receptor (PPAR)-gamma. We expanded on the structure-activity relationships of ...

Abstract This article aimed at the synthesis and molecular docking assessment of new diimine Schiff base ligand, namely 2-(( E )-(2-(( Z )-2-(4-chlorophenyl)-2-hydroxyvinyl)hydrazono) methyl)-6-methoxyphenol (methoxy-diim), via condensation 1-(4-chloro-phenyl)-2-hydrazino-ethenol compound with )-2-(4-chlorophenyl)-2-hydroxy vinyl) hydrazono)methyl)-6-methoxyphenol in acetic acid as well prepara...