Here we report a new method combining strain and defect engineering for the periodic modulation of graphene nanoscale rippling. First, gold nanoparticles 16 nm in diameter were synthesized by seed-mediated, wet-chemical approach, thiol-terminated polyethylene glycol (mPEG-SH) molecules grafted onto their surface. High-density monolayers PEGylated successfully prepared on Si substrates Langmuir-...

The use of methoxypoly(ethylene glycol) (mPEG) in PEG conjugates of proteins and non-protein therapeutic agents has led to the recognition that the polymer components of such conjugates can induce anti-PEG antibodies (anti-PEGs) that may accelerate the clearance and reduce the efficacy of the conjugates. Others have classified anti-PEGs as "methoxy-specific" or "backbone-specific". The results ...

Systemic administration of chemotherapy for cancer often has toxic side effects, limiting the doses that can be used in its treatment. In this study, we developed methoxy poly(ethylene glycol)-poly(caprolactone) (MPEG-PCL) micelles loaded with curcumin and doxorubicin (Cur-Dox/MPEG-PCL) that were tolerated by recipient mice and had enhanced antitumor effects and fewer side effects. It was shown...

The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. Therefore, there is a critical need to develop an efficient drug delivery system to circumvent drug resistance. The anticoccidial drug monensin, a carboxylic ionophore, has been shown to have antimalarial properties. Here, we developed a liposome-based drug delivery of monensi...

The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain. Intranasal application of nano-sized micelles that have been modified with Tat peptide facilitates brain deli...

This study aimed to develop a cationic nanosuspension of chitosan (CS) and methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) for ocular delivery of diclofenac (DIC). MPEG-PCL-CS block polymer was synthesized by covalent coupling of MPEG-PCL with CS. The critical micelle concentration of the MPEG-PCL-CS block polymer was 0.000692 g/L. DIC/MPEG-PCL-CS nanosuspension (mean particle siz...

Organic molecules that are active in the near-infrared (NIR) bio-window for photo-to-heat energy-converting theranostics have attracted much attention cancer therapy. However, current organic NIR-absorbing still suffering from inefficient non-radiative decay or serious photobleaching under light irradiation. Herein, we design a convenient strategy to load new kind of nonlinear optical (NLO) chr...

Combination chemotherapy is an important protocol in glioma therapy and honokiol shows synergistic anticancer effects with doxorubicin. In this paper, honokiol (HK) and doxorubicin (Dox) co-loaded Methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) nanoparticles were prepared with a assembly method. The particle size (about 34 nm), morphology, X-ray Powder Diffraction (XRD), in vitro ...

This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-a-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-a-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(l...