This study was done to investigate the effects of water-soluble fraction (WSF) of the fruits of Abelmoschus esculentus L (okra/lady's fingers) on absorption of oral glucose as well as metformin from the gastrointestinal tract in the Long Evans rats. WSF of A. esculentus significantly (P < 0.05) reduced the absorption of glucose as studied in the 24 hrs fasting rats. The effect of WSF of A. escu...

We attempt to discuss the effect of metformin combined with dapagliflozin on homocysteine, cystatin-c and beta-2 microglobulin levels in patients type 2 diabetes mellitus. selected 150 mellitus treated our hospital from July 2018 October 2021. According random number table method, we divided them into observation group (metformin tablets tablets) control hydrochloride tablets), 75 cases each gr...

This randomized, double-blind, phase III study evaluated the efficacy and safety of once-daily treatment with alogliptin (25 mg once daily), alone or with metformin hydrochloride (500 mg once daily or 250 mg twice daily), in Japanese patients with type 2 diabetes. The primary endpoint was change in glycated haemoglobin (HbA1c) from baseline to the end of treatment (week 24). The least squares (...

A simple, rapid, accurate and precise analytical method for determination of secondary and tertiary amines in hydrochloride salt form of drug substances in non-aqueous medium, which does not require any derivatization, was developed by headspace gas chromatography. Dimethylamine hydrochloride and triethylamine hydrochloride were analyzed in metformin hydrochloride. The sample was dissolved in a...

Abstract: Introduction: Diabetes Mellitus (DM) is one of the most prevalent and chronic illnesses associated with an abnormally high level glucose in body which hazardous to organs. Metformin Hydrochloride (HCl), a biguanide derivative used for Type 2 DM. It has relatively short plasma half-life its regular administration required maintain normal blood diabetic patients. Therefore, sustained-re...

Metformin is 1,1-dimethylbiguanide hydrochloride, the first-line therapy for type 2 diabetes. Additionally, several studies focused on role of metformin in antioxidant activities treatment hepatic disorders. The experimentally&#x0D; &#x0D; -based result valproic acid's liver injury, a front-line medicine epilepsy, attracted lot interest. As result, effect acid-induced redox disturbances rat tis...

The purpose of this research was to formulate and characterize solid dispersion (SD) of metformin hydrochloride using methocel K100M as the carrier by the solvent evaporation and cogrinding method. The influence of drug polymer ratio on drug release was studied by dissolution tests. Characterization was performed by fourier transform spectroscopy (FTIR), ultraviolet, differential scanning calor...

OBJECTIVES To evaluate the role of anti-Mullerian hormone (AMH) and inhibin B in the evaluation of the effectiveness of short- (3 months) and long-term (6 months or more) metformin therapy in Iraqi women with polycystic ovarian syndrome (PCOS). METHODS This cross-sectional study was carried out at the Biochemistry Department, College of Medicine, University of Baghdad, Baghdad, Iraq from June...