background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

background: in the last decades, mesoporous silica nanoparticles (msn) are improved for drug delivery, imaging, and biomedical applications due to their special properties such as large surface area, high drug loading capacity, tunable pore size, and modification of surface area by functional groups. objectives: the aim of this study was to evaluate msns as carriers for oral colon-specific and ...

Gadolinium oxide (Gd2O3) nanoparticles with very small size and narrow size distribution were synthesized by infiltration of Gd(NO3)3·6H2O as an oxide precursor into the pores of SBA-15 mesoporous silica using a wet-impregnation technique. High resolution transmission electron microscopy and X-ray diffraction show that during the hydrothermal treatment of the precursor at 550 °C, gadolinium oxi...

Both bulk and mesoporous silica nanoparticles can be obtained in the form of granular aggregates using chitosan flakes as additive under very soft biomimetic reaction conditions.

An intelligent pH-responsive carrier and release system based on DNA nanoswitch-controlled organization of gold nanoparticles (AuNPs) attached to mesoporous silica (MS) has been designed and demonstrated.

In this study the effect of surface modification of mesoporous silica nanoparticles (MSNs) on its adsorption capacities and protein stability after immobilization of beta-lactoglobulin B (BLG-B) was investigated. For this purpose, non-functionalized (KIT-6) and aminopropyl-functionalized cubic Ia3d mesoporous silica ([n-PrNH2-KIT-6]) nanoparticles were used as nanoporous supports. Aminopropyl-f...

Changes in the conformation of a peptide anchored onto the external surface of mesoporous silica nanoparticles have been used to design novel temperature-controlled delivery systems.

Silicon-based mesoporous nanoparticles have been extensively studied to meet the challenges in the drug delivery. Functionality of these nanoparticles depends on their properties which are often changing as a function of particle size and surrounding medium. Widely used characterization methods, dynamic light scattering (DLS), and transmission electron microscope (TEM) have both their weaknesse...

Well-dispersed mesoporous hollow silica-fullerene nanoparticles with particle sizes of ∼50 nm have been successfully prepared by incorporating fullerene molecules into the silica framework followed by a selective etching method. The fabricated fluorescent silica-fullerene composite with high porosity demonstrates excellent performance in combined chemo/photodynamic therapy.

Mesoporous silica thin films and nanoparticles prepared by surfactant-templated sol–gel techniques are versatile substrates that can be easily erivatized with active molecules to create functional materials. By exploiting the chemical and physical differences that exist in different regions f the mesostructure, active molecules can be deliberately placed using one-pot techniques, or they can be...