human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...

high-dose chemotherapy and autologous stem cell transplantation (sct) have become an effective care for many patients with hematological malignancies. harvesting the stem cells is one the most important parts of sct. the two most commonly used mobilization regimens are the use of granulocyte colony-stimulating factor (g-csf) or g-csf plus chemotherapy. however, about 10-30% of patients are unab...

introduction: this review reports the current results of hematopoietic stem cell transplantation (hsct) in patients who had received transplantation in the hematology-oncology and sct research center, tehran, iran. methods: in iran, from 1991 through 2010, a total of 3170 hematopoietic stem cell transplantation have been carried out. the male/female patient ratio was 1909/1261 with a median age...

background: cell-based treatments are currently being actively received great attention among scientists and clinicians for a variety of diseases as well as diabetes .the aim of this study was to investigate the effect of allotransplantation of fetal liver-derived cell suspension in patients with type 1 diabetes. methods: patients with type 1 diabetes (n=16) aged 6-30 years-old were included in...

conclusions our results suggested that cb-nk cells progenitors could proliferate and differentiate on feeder layer of amnion membrane mscs in combination with specific cytokines to produce nk cells for immunotherapy. results combination of cytokines and msc layer yielded significant fold expansion in comparison with cytokines without feeder conditions (day 7: 5.2 ± 1.12 and 2 ± 0.78, respective...

evidence acquisition the fifty two significant articles discussing the stem cell in chronic myeloid leukemia from 1996 to 2012 were selected according to the authors’ experience. results studies have shown that primitive cml cells are less responsive to tyrosine kinase inhibitors (tkis) and are a reservoir for the relapse of multi drug resistant (mdr). conclusions following that, minimal residu...

background: perioglasâ (pg) is an alloplastic material used for grafting periodontal osseous defects since 1995. in animal models, it has been proven that pg achieves histologically good repair of surgically created defects. in clinical trials, pg was effective as an adjunct to conventional surgery in the treatment of intrabony defects. because the molecular events due to pg that are able to al...

background: retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hucm). methods: after isolation, hucm were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. also, doubling time of the cells and their differentiation potential into adipoge...

background: stem cell therapy is a new treatment option for different diseases. the aim of this systematic review is assessing the articles that focus on sct in iran and evaluate the amount of their success, failure and complication. methods: systematic search was conducted for finding english and persian papers (controlled trials and cohort studies with follow up) published before march 2015. ...