Abstract: Background: Inflammatory bowel disease (IBD) is a chronic inflammatory of large intestine consisting ulcerative colitis and Crohn’s disease. Mesalamine first line drug use for the treatment but it has drawback low water solubility permeability. In addition, oral delivery to colon faces problem gastric degradation thus increases dose size frequency. Objectives: The present study was ai...

Mesalamine is a gold standard anti-inflammatory drug used to treat inflammatory bowel illnesses. It's usually and keep Ulcerative Colitis in remission mild moderate cases. rapidly cleared from circulation after being consumed orally, with an elimination half-life of only one hour. Oral intake delayed or slow released matrix formulations can acquire therapeutic concentration the intestines. The ...

BACKGROUND Limited data are available on mesalamine (5-aminosalicylic acid; 5-ASA) use in pediatric ulcerative colitis (UC). AIM To evaluate pharmacokinetic and safety profiles of 5-ASA and metabolite acetyl-5-ASA (Ac-5-ASA) after once-daily, oral administration of multimatrix mesalamine to children and adolescents with UC. METHODS Participants (5-17 years of age; 18-82 kg, stratified by we...

OBJECTIVE The aim of the study was to assess the safety and efficacy of high- and low-dose oral, delayed-release mesalamine in a randomized, double-blind, active control study of children with mild-to-moderately active ulcerative colitis. METHODS Patients ages 5 to 17 years, with a Pediatric Ulcerative Colitis Activity Index (PUCAI) score of ≥ 10 to ≤ 55 and a truncated Mayo Score of ≥ 1 for ...

56 INTRODUCTION Inflammatory bowel disease (IBD) is a collective term for the two conditions: Crohn’s disease and ulcerative colitis. Crohn’s disease is a transmural inflammatory disease that can affect the small intestine only (30%), the colon only (25%), or both the small intestine and the colon at the same time (40%). Ulcerative colitis is an inflammatory disease of the colonic mucosa with n...

H(2)S functions as a neuromodulator and exerts anti-inflammatory activities. Recent data indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. In this study, we have investigated the role of a novel H(2)S-releasing derivative of mesalamine (5-amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester, ATB-429) in modulating nocicept...

Ulcerative colitis (UC) is a chronic inflammatory condition of unclear etiology affecting the large bowel, most commonly the rectum and extending proximally in a continuous fashion. The overall principle in the pathophysiolgy of ulcerative colitis is the dysregulation of the normal immune system against an antigenic trigger leading to a prolonged mucosal inflammatory response. The diagnosing of...

Hydrogen sulfide (H2S) functions as a neuromodulator and exerts anti-inflammatory activities. Recent data indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. In this study we have investigated the role of a novel H2Sreleasing derivative of mesalamine (ATB-429) in modulating nociception to colorectal distension (CRD), a model that mimics some fea...