Multiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence two or more gland tumors in patient related individuals same family. They are inherited an autosomal dominant fashion and highly penetrant. There three types MEN syndromes: type 1 (MEN1), 2 (MEN2), 4 (MEN4). MEN2 further divided into MEN2A, MEN2B (formerly known MEN3), familial medullary thyr...

Sommario L’iperparatiroidismo primitivo (IPP), condizione caratterizzata da aumentata secrezione di paratormone e conseguente aumento dei valori calcemia, può presentarsi sia in forma sporadica che familiare. Tra le forme familiari, l’IPP rappresenta una manifestazione caratteristica delle sindromi neoplasie endocrine multiple (MEN) tipo 1, 2A 4. Le caratteristiche cliniche dell’IPP differiscon...

Multiple endocrine neoplasia type 2 (MEN2) is a rare familial syndrome caused by mutations in the RET protooncogene and it is transmitted as an autosomal dominant trait. The underlying problem for all the MEN syndromes is failure of a tumour suppressor gene. The genetic defect in MEN2 is on chromosome 10 (10q11.2) and has also been identified both for MEN2A and MEN2B. The reported patient is an...

Editor—We report a case of MEN2A syndrome who underwent bilateral laparoscopic adrenalectomy and staggered total thyroidectomy and radical neck dissection with intraoperative nerve monitoring. Multiple Endocrine Neoplasia (MEN) is a syndrome which involves more than one endocrine gland. There are 3 types and further subtypes of MEN. MEN2A is characterized by medullary thyroid cancer (97%) with ...