PURPOSE To investigate the link between microsatellite instability and epigenetic silencing of the MLH1 gene in the human retinoblastoma genome. METHODS Methylation at the 5' region of MLH1 was studied, along with its protein expression level by using immunohistochemical staining in 51 retinoblastoma tumors and 2 retinoblastoma cell lines. Also assessed was the genomic stability of 26 retinob...

Abstract In view of extending the relatively brief postharvest life flowers by a range technologies, present study elucidates implication 6-benzylamino purine (BAP), kinetin (KN) and thidiazuron (TDZ) on performance flower longevity isolated Calendula officinalis. BAP KN belong to adenine group cytokinins while as TDZ is diphenyl urea compound having cytokinin like activity. The harvested were ...

The aims of this study were to identify (1) patient-related factors (sex, age, craniofacial pattern and smoking habit), (2) miniscrews implants (MSI)-related factors (length and diameter) and (3) location-related factors [bone (maxilla or mandible) and area (buccal, lingual and alveolar ridge)] that may be associated with MSI loss of stability. A total of 1356 MSI were installed in 570 patients...

Defects in the function of mismatch repair (MMR) genes result in genetic instability, a common feature of malignant progression. This study was conducted to determine the frequency of genetic instability [defined as microsatellite instability (MSI)] and to evaluate the sensitivity/specificity of immunohistochemistry in predicting the deficiency in MMR genes in renal cortical tumors. A total of ...

Wheat is one of the main staple cereal crops worldwide. However, drought-induced stress factors limiting wheat productivity, especially in arid and semi-arid regions. The present study aims to investigate influence arbuscular mycorrhizal fungi (AMF) on plant growth under water-deficit conditions. Three Algerian durum varieties—Mohamed Ben Bachir (MBB), Boussellem (BS) Waha (W)—were grown with (...

salinity is a major environmental problem in arid and semi-arid areas. chickpea (cicer arietinum l.), like other legumes is sensitive to salinity. therefore, selection of genotypes to grow on saline areas is important. eleven chickpea genotypes (as sub plots) were grown in the greenhouse conditions on a medium containing different nacl concentrations (8 and 12 dsm-1) and control (hoagland solut...

Microsatellites instability (MSI) is a risk factor for multiple primary cancers (MPCs). However, a variety of studies focused on the risk in the hereditary non-polyposis colorectal cancer (HNPCC) not the sporadic colorectal cancer (CRC) patients. The aim of this meta-analysis was to comprehensive overview and quantitative summary the association between MSI and risk of MPCs. A comprehensive lit...

Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also has a striking effect on ribosomes. MSI-78's effect on DSC scans of bacteria was similar to that of kanamycin, an antibiotic drug known to target ...

Lysosomes are sensitive to environmental stresses. Lysosomal membrane stability measured using lysosomal enzyme release assay (LERA) and expressed in terms of lysosomal lability index is employed as an early warning system for detection of disturbances in the surrounding environment. In the present study, lysosomal membrane stability of animals belonging to different phyla namely, Rattus norweg...